Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

Hiroshi Aoyama; Kumiko Sako; Shinichi Sato; Masahiko Nakamura; Hiroyuki Miyachi; Yukinori Goto; Mika Okamoto; Masanori Baba; Yuichi Hashimoto

doi:10.3987/COM-08-S(F)68

Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

Hiroshi Aoyama, Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba, Yuichi Hashimoto

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

Original language	English
Pages (from-to)	779-785
Number of pages	7
Journal	Heterocycles
Volume	77
Issue number	2
DOIs	https://doi.org/10.3987/COM-08-S(F)68
Publication status	Published - 2009 Feb 1
Externally published	Yes

Keywords

Anti-BVDV Agent
Buchwald-Hartwig Amination
Palladium-Catalyzed
Quantitative Structure-Activity Relationship (QSAR)
γ-Carboline

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3987/COM-08-S(F)68

Cite this

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title = "Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity",

abstract = "Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.",

keywords = "Anti-BVDV Agent, Buchwald-Hartwig Amination, Palladium-Catalyzed, Quantitative Structure-Activity Relationship (QSAR), γ-Carboline",

author = "Hiroshi Aoyama and Kumiko Sako and Shinichi Sato and Masahiko Nakamura and Hiroyuki Miyachi and Yukinori Goto and Mika Okamoto and Masanori Baba and Yuichi Hashimoto",

year = "2009",

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doi = "10.3987/COM-08-S(F)68",

language = "English",

volume = "77",

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journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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TY - JOUR

T1 - Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

AU - Aoyama, Hiroshi

AU - Sako, Kumiko

AU - Sato, Shinichi

AU - Nakamura, Masahiko

AU - Miyachi, Hiroyuki

AU - Goto, Yukinori

AU - Okamoto, Mika

AU - Baba, Masanori

AU - Hashimoto, Yuichi

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

AB - Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

KW - Anti-BVDV Agent

KW - Buchwald-Hartwig Amination

KW - Palladium-Catalyzed

KW - Quantitative Structure-Activity Relationship (QSAR)

KW - γ-Carboline

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UR - http://www.scopus.com/inward/citedby.url?scp=65749119604&partnerID=8YFLogxK

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DO - 10.3987/COM-08-S(F)68

M3 - Article

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SN - 0385-5414

VL - 77

SP - 779

EP - 785

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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