Porous polymer microneedles with interconnecting microchannels for rapid fluid transport

Liming Liu; Hiroyuki Kai; Kuniaki Nagamine; Yudai Ogawa; Matsuhiko Nishizawa

doi:10.1039/c6ra07882f

Porous polymer microneedles with interconnecting microchannels for rapid fluid transport

Liming Liu, Hiroyuki Kai, Kuniaki Nagamine, Yudai Ogawa, Matsuhiko Nishizawa

ENG - Finemechanics

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

A porous polymer microneedle array with an average pore diameter of ∼1 μm was fabricated by photopolymerization of an acrylate monomer in the presence of a porogen within a mold. Porosity measurement and water absorption testing revealed that the pores are interconnected throughout the microneedle, which enabled rapid wetting of the microneedle by capillary action. The porosity of the polymer microneedles can be modulated by varying porogen content, and this allowed balancing fast water absorption speed and sufficient mechanical strength to penetrate a skin. The developed porous polymer microneedle array is a potentially versatile tool for rapid fluid transport from and into a body through the skin.

Original language	English
Pages (from-to)	48630-48635
Number of pages	6
Journal	RSC Advances
Volume	6
Issue number	54
DOIs	https://doi.org/10.1039/c6ra07882f
Publication status	Published - 2016

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/c6ra07882f

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title = "Porous polymer microneedles with interconnecting microchannels for rapid fluid transport",

abstract = "A porous polymer microneedle array with an average pore diameter of ∼1 μm was fabricated by photopolymerization of an acrylate monomer in the presence of a porogen within a mold. Porosity measurement and water absorption testing revealed that the pores are interconnected throughout the microneedle, which enabled rapid wetting of the microneedle by capillary action. The porosity of the polymer microneedles can be modulated by varying porogen content, and this allowed balancing fast water absorption speed and sufficient mechanical strength to penetrate a skin. The developed porous polymer microneedle array is a potentially versatile tool for rapid fluid transport from and into a body through the skin.",

author = "Liming Liu and Hiroyuki Kai and Kuniaki Nagamine and Yudai Ogawa and Matsuhiko Nishizawa",

note = "Funding Information: We thank Taro Kondo for his assistance for porosity measurement. This work was partly supported by Center of Innovation Program (COI), Creation of Innovation Centers for Advanced Interdisciplinary Research Area Program from Japan Science and Technology Agency, JST, Regional Innovation Strategy Support Program {"}Knowledge-based Medical Device Cluster/Miyagi Area{"}, and by Grand-in-Aid for Scientific Research A (25246016) and Challenging Exploratory Research (K15K13315) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6ra07882f",

language = "English",

volume = "6",

pages = "48630--48635",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "54",

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TY - JOUR

T1 - Porous polymer microneedles with interconnecting microchannels for rapid fluid transport

AU - Liu, Liming

AU - Kai, Hiroyuki

AU - Nagamine, Kuniaki

AU - Ogawa, Yudai

AU - Nishizawa, Matsuhiko

N1 - Funding Information: We thank Taro Kondo for his assistance for porosity measurement. This work was partly supported by Center of Innovation Program (COI), Creation of Innovation Centers for Advanced Interdisciplinary Research Area Program from Japan Science and Technology Agency, JST, Regional Innovation Strategy Support Program "Knowledge-based Medical Device Cluster/Miyagi Area", and by Grand-in-Aid for Scientific Research A (25246016) and Challenging Exploratory Research (K15K13315) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - A porous polymer microneedle array with an average pore diameter of ∼1 μm was fabricated by photopolymerization of an acrylate monomer in the presence of a porogen within a mold. Porosity measurement and water absorption testing revealed that the pores are interconnected throughout the microneedle, which enabled rapid wetting of the microneedle by capillary action. The porosity of the polymer microneedles can be modulated by varying porogen content, and this allowed balancing fast water absorption speed and sufficient mechanical strength to penetrate a skin. The developed porous polymer microneedle array is a potentially versatile tool for rapid fluid transport from and into a body through the skin.

AB - A porous polymer microneedle array with an average pore diameter of ∼1 μm was fabricated by photopolymerization of an acrylate monomer in the presence of a porogen within a mold. Porosity measurement and water absorption testing revealed that the pores are interconnected throughout the microneedle, which enabled rapid wetting of the microneedle by capillary action. The porosity of the polymer microneedles can be modulated by varying porogen content, and this allowed balancing fast water absorption speed and sufficient mechanical strength to penetrate a skin. The developed porous polymer microneedle array is a potentially versatile tool for rapid fluid transport from and into a body through the skin.

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DO - 10.1039/c6ra07882f

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VL - 6

SP - 48630

EP - 48635

JO - RSC Advances

JF - RSC Advances

IS - 54

ER -

Porous polymer microneedles with interconnecting microchannels for rapid fluid transport

Abstract

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