Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

Sodai Takyu; Hayato Ikeda; Hidekatsu Wakizaka; Fumihiko Nishikido; Ken Ichiro Matsumoto; Hideaki Tashima; Hisashi Suzuki; Yoshihito Funaki; Hiroshi Watabe; Miwako Takahashi; Taiga Yamaya

doi:10.35848/1882-0786/ad047c

Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

Sodai Takyu, Hayato Ikeda, Hidekatsu Wakizaka, Fumihiko Nishikido, Ken Ichiro Matsumoto, Hideaki Tashima, Hisashi Suzuki, Yoshihito Funaki, Hiroshi Watabe, Miwako Takahashi, Taiga Yamaya

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of ¹²⁴I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of positron annihilation lifetime measurement with ¹²⁴I was compared with ²²Na, which is often used in positron annihilation lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that the accuracy of the lifetime value estimation was slightly worse than that for ²²Na, while the positron annihilation lifetime measurement using ¹²⁴I was a feasible choice.

Original language	English
Article number	116001
Journal	Applied Physics Express
Volume	16
Issue number	11
DOIs	https://doi.org/10.35848/1882-0786/ad047c
Publication status	Published - 2023 Nov 1

Keywords

iodine-124
positron annihilation lifetime
positron emission tomography (PET)
positronium (Ps)

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10.35848/1882-0786/ad047c

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title = "Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use",

abstract = "Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of 124I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of positron annihilation lifetime measurement with 124I was compared with 22Na, which is often used in positron annihilation lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that the accuracy of the lifetime value estimation was slightly worse than that for 22Na, while the positron annihilation lifetime measurement using 124I was a feasible choice.",

keywords = "iodine-124, positron annihilation lifetime, positron emission tomography (PET), positronium (Ps)",

author = "Sodai Takyu and Hayato Ikeda and Hidekatsu Wakizaka and Fumihiko Nishikido and Matsumoto, {Ken Ichiro} and Hideaki Tashima and Hisashi Suzuki and Yoshihito Funaki and Hiroshi Watabe and Miwako Takahashi and Taiga Yamaya",

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doi = "10.35848/1882-0786/ad047c",

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T1 - Positron annihilation lifetime measurement with TOF-PET detectors

T2 - feasibility of Iodine-124 use

AU - Takyu, Sodai

AU - Ikeda, Hayato

AU - Wakizaka, Hidekatsu

AU - Nishikido, Fumihiko

AU - Matsumoto, Ken Ichiro

AU - Tashima, Hideaki

AU - Suzuki, Hisashi

AU - Funaki, Yoshihito

AU - Watabe, Hiroshi

AU - Takahashi, Miwako

AU - Yamaya, Taiga

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of 124I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of positron annihilation lifetime measurement with 124I was compared with 22Na, which is often used in positron annihilation lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that the accuracy of the lifetime value estimation was slightly worse than that for 22Na, while the positron annihilation lifetime measurement using 124I was a feasible choice.

AB - Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of 124I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of positron annihilation lifetime measurement with 124I was compared with 22Na, which is often used in positron annihilation lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that the accuracy of the lifetime value estimation was slightly worse than that for 22Na, while the positron annihilation lifetime measurement using 124I was a feasible choice.

KW - iodine-124

KW - positron annihilation lifetime

KW - positron emission tomography (PET)

KW - positronium (Ps)

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JO - Applied Physics Express

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Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

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Keywords

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