Practical Methods for Chemical Inactivation of Creutzfeldt-Jakob Disease Pathogen

Jun Tateishi, Takatoshi Tashima, Tetsuyuki Kitamoto

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Chemical inactivation of pathogen of Creutzfeldt-Jakob disease (CJD) was examined using the mouse-adapted CJD strain. A high concentration of formic acid, guanidine compounds, trichloroacetate and phenol prevented CJD transmission. NaOH between 0.25 and 2 n lengthened the incubation periods. Sodium dodecyl sulfate (SDS) in a concentration between 1 and 3% did not alter incubation at room temperature but did completely block the transmission after boiling for 3 min in 3% SDS. This method is recommended for practical disinfection.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
Issue number2
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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