Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones and ketoimines

Nobuki Kato; Daisuke Tomita; Keisuke Maki; Motomu Kanai; Masakatsu Shibasaki

doi:10.1021/jo049258o

Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones and ketoimines

Nobuki Kato, Daisuke Tomita, Keisuke Maki, Motomu Kanai, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

A practical synthesis of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones and ketoimines is described. Compared with the previous synthetic route, the number of total steps is decreased and the total yield is greatly improved. Furthermore, both (+)- and (-)-ligands are readily available by this new synthetic route.

Original language	English
Pages (from-to)	6128-6130
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	69
Issue number	18
DOIs	https://doi.org/10.1021/jo049258o
Publication status	Published - 2004 Sept 3
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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abstract = "A practical synthesis of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones and ketoimines is described. Compared with the previous synthetic route, the number of total steps is decreased and the total yield is greatly improved. Furthermore, both (+)- and (-)-ligands are readily available by this new synthetic route.",

author = "Nobuki Kato and Daisuke Tomita and Keisuke Maki and Motomu Kanai and Masakatsu Shibasaki",

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AU - Kato, Nobuki

AU - Tomita, Daisuke

AU - Maki, Keisuke

AU - Kanai, Motomu

AU - Shibasaki, Masakatsu

PY - 2004/9/3

Y1 - 2004/9/3

N2 - A practical synthesis of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones and ketoimines is described. Compared with the previous synthetic route, the number of total steps is decreased and the total yield is greatly improved. Furthermore, both (+)- and (-)-ligands are readily available by this new synthetic route.

AB - A practical synthesis of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones and ketoimines is described. Compared with the previous synthetic route, the number of total steps is decreased and the total yield is greatly improved. Furthermore, both (+)- and (-)-ligands are readily available by this new synthetic route.

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Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones and ketoimines

Abstract

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