Prandial increases of leptin and orexin in the brain modulate spatial learning and memory

Yutaka Oomura, Shuji Aou, Kouji Fukunaga, Sigeki Moriguchi, Kazuo Sasaki

Research output: Contribution to journalArticlepeer-review


Leptin is well known to be involved in the inhibition of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodent hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus long-term potentiation (LTP) and the phosphorylation of Ca2+/calmodulin protein kinase II (CaMK II) were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area (LHA) and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation without affecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory was impaired. The present studies suggest that leptin and orexin signalings in the brain may have important implications for cognitive function.

Original languageEnglish
Pages (from-to)S1-S10
JournalHirosaki Medical Journal
Issue numberSUPPL.
Publication statusPublished - 2010 Jul 8


  • CaMK II phosphorylation
  • Facilitation and impairment of learning and memory in rodents
  • Leptin
  • Orexin


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