PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

Gurdeep Singh, Asuka Inoue, J. Silvio Gutkind, Robert B. Russell, Francesco Raimondi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


G-protein coupled receptors (GPCRs) control multiple physiological states by transducing a multitude of extracellular stimuli into the cell via coupling to intra-cellular heterotrimeric G-proteins. Deciphering which G-proteins couple to each of the hundreds of GPCRs present in a typical eukaryotic organism is therefore critical to understand signalling. Here, we present PRECOG ( a web-server for predicting GPCR coupling, which allows users to: (i) predict coupling probabilities for GPCRs to individual G-proteins instead of subfamilies; (ii) visually inspect the protein sequence and structural features that are responsible for a particular coupling; (iii) suggest mutations to rationally design artificial GPCRs with new coupling properties based on predetermined coupling features.

Original languageEnglish
Pages (from-to)W395-W401
JournalNucleic acids research
Issue numberW1
Publication statusPublished - 2019 Jul 1

ASJC Scopus subject areas

  • Genetics


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