Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment

Natsuko Ito; Masanobu Kamitakahara; Koji Ioku

doi:10.1016/j.matlet.2014.01.040

Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment

Natsuko Ito, Masanobu Kamitakahara, Koji Ioku

ENV - Environmental Studies for Advanced Society

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Spherical porous granules composed of octacalcium phosphate (OCP) and hydroxyapatite (HA) are predicted to be useful as drug carriers for treating bone cancer. We successfully prepared spherical porous OCP/HA granules by immersing α-tricalcium phosphate spherical granules in a pH 5.0 buffered solution at 60 C. When human osteosarcoma (HOS) cells were cultured in the medium in which the methotrexate-loaded granules were immersed, cell proliferation was significantly inhibited. The release of methotrexate from the granules continued for at least 48 h. On the other hand, the medium immersed in the methotrexate-free granules did not inhibit the cell proliferation. These results suggest that the spherical porous OCP/HA granules are safe and act as drug carriers releasing the drugs continuously.

Original language	English
Pages (from-to)	94-96
Number of pages	3
Journal	Materials Letters
Volume	120
DOIs	https://doi.org/10.1016/j.matlet.2014.01.040
Publication status	Published - 2014 Apr 1

Keywords

Biomaterials
Bone
Drug carrier
Hydroxyapatite
Octacalcium phosphate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.matlet.2014.01.040

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title = "Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment",

abstract = "Spherical porous granules composed of octacalcium phosphate (OCP) and hydroxyapatite (HA) are predicted to be useful as drug carriers for treating bone cancer. We successfully prepared spherical porous OCP/HA granules by immersing α-tricalcium phosphate spherical granules in a pH 5.0 buffered solution at 60 C. When human osteosarcoma (HOS) cells were cultured in the medium in which the methotrexate-loaded granules were immersed, cell proliferation was significantly inhibited. The release of methotrexate from the granules continued for at least 48 h. On the other hand, the medium immersed in the methotrexate-free granules did not inhibit the cell proliferation. These results suggest that the spherical porous OCP/HA granules are safe and act as drug carriers releasing the drugs continuously.",

keywords = "Biomaterials, Bone, Drug carrier, Hydroxyapatite, Octacalcium phosphate",

author = "Natsuko Ito and Masanobu Kamitakahara and Koji Ioku",

note = "Funding Information: This work was partly supported by KAKENHI ( 11J04659 ) and the Nippon Sheet Glass Foundation for Materials Science and Engineering .",

year = "2014",

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doi = "10.1016/j.matlet.2014.01.040",

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journal = "Materials Letters",

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TY - JOUR

T1 - Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment

AU - Ito, Natsuko

AU - Kamitakahara, Masanobu

AU - Ioku, Koji

N1 - Funding Information: This work was partly supported by KAKENHI ( 11J04659 ) and the Nippon Sheet Glass Foundation for Materials Science and Engineering .

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Spherical porous granules composed of octacalcium phosphate (OCP) and hydroxyapatite (HA) are predicted to be useful as drug carriers for treating bone cancer. We successfully prepared spherical porous OCP/HA granules by immersing α-tricalcium phosphate spherical granules in a pH 5.0 buffered solution at 60 C. When human osteosarcoma (HOS) cells were cultured in the medium in which the methotrexate-loaded granules were immersed, cell proliferation was significantly inhibited. The release of methotrexate from the granules continued for at least 48 h. On the other hand, the medium immersed in the methotrexate-free granules did not inhibit the cell proliferation. These results suggest that the spherical porous OCP/HA granules are safe and act as drug carriers releasing the drugs continuously.

AB - Spherical porous granules composed of octacalcium phosphate (OCP) and hydroxyapatite (HA) are predicted to be useful as drug carriers for treating bone cancer. We successfully prepared spherical porous OCP/HA granules by immersing α-tricalcium phosphate spherical granules in a pH 5.0 buffered solution at 60 C. When human osteosarcoma (HOS) cells were cultured in the medium in which the methotrexate-loaded granules were immersed, cell proliferation was significantly inhibited. The release of methotrexate from the granules continued for at least 48 h. On the other hand, the medium immersed in the methotrexate-free granules did not inhibit the cell proliferation. These results suggest that the spherical porous OCP/HA granules are safe and act as drug carriers releasing the drugs continuously.

KW - Biomaterials

KW - Bone

KW - Drug carrier

KW - Hydroxyapatite

KW - Octacalcium phosphate

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DO - 10.1016/j.matlet.2014.01.040

M3 - Article

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SN - 0167-577X

VL - 120

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EP - 96

JO - Materials Letters

JF - Materials Letters

ER -

Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment

Abstract

Keywords

UN SDGs

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