TY - JOUR
T1 - Preparation of 1,4-bis(2-ethynyl-3-thienyl)benzenes as versatile spacers for connection of heterocycles
AU - Toyota, Kozo
AU - Goto, Yoichi
AU - Okada, Kazuyuki
AU - Morita, Noboru
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Iodination of 1,4-di(3-thienyl)benzene gave 1,4-bis(2-iodo-3-thienyi)-benzene, which was converted to 1,4-bis(2-ethynyl-3-thienyl)benzene. Novel 1,4-bis|2-(pyridylethynyl)-3-thienyl)benzene ligands containing the bis(ethynylthienyl)benzene spacer were prepared by Sonogashira reaction. Advantage of the spacer was demonstrated by introducing functionalized alkyl groups to the 5-position of the thiophene ring of 1,4-bis|2-(trialkylsilylethynyl)-3-thienyl|benzene.
AB - Iodination of 1,4-di(3-thienyl)benzene gave 1,4-bis(2-iodo-3-thienyi)-benzene, which was converted to 1,4-bis(2-ethynyl-3-thienyl)benzene. Novel 1,4-bis|2-(pyridylethynyl)-3-thienyl)benzene ligands containing the bis(ethynylthienyl)benzene spacer were prepared by Sonogashira reaction. Advantage of the spacer was demonstrated by introducing functionalized alkyl groups to the 5-position of the thiophene ring of 1,4-bis|2-(trialkylsilylethynyl)-3-thienyl|benzene.
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U2 - 10.1016/S0385-5414(07)81098-7
DO - 10.1016/S0385-5414(07)81098-7
M3 - Article
AN - SCOPUS:37349077622
SN - 0385-5414
VL - 71
SP - 2227
EP - 2236
JO - Heterocycles
JF - Heterocycles
IS - 10
ER -