Preparation of 2-iodo-1,3-butadienes from 1-trimethylsilyl-2,3- butadienes and their functionalizations

Takashi Nishiyama; Tomoyuki Esumi; Yoshiharu Iwabuchi; Hiroshi Irie; Susumi Hatakeyama

doi:10.1016/S0040-4039(97)10413-0

Preparation of 2-iodo-1,3-butadienes from 1-trimethylsilyl-2,3- butadienes and their functionalizations

Takashi Nishiyama, Tomoyuki Esumi, Yoshiharu Iwabuchi, Hiroshi Irie, Susumi Hatakeyama

PHA - Molecular Pharmaceutical Science

Nagasaki University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Successive treatment of 1-trimethylsilyl-2.3-butadienes with iodine and tetra-n-butylammonium fluoride in the same flask affords 2-iodo-1.3- butadienes in good yields and their palladium-catalyzed carbonylation and alkynylation allows introduction of ester and alkynyl groups to the 2- position bearing an iodine atom leading to various 2.3-disubstituted 1,3- butadienes.

Original language	English
Pages (from-to)	43-46
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	1-2
DOIs	https://doi.org/10.1016/S0040-4039(97)10413-0
Publication status	Published - 1998 Jan 1

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AU - Nishiyama, Takashi

AU - Esumi, Tomoyuki

AU - Iwabuchi, Yoshiharu

AU - Irie, Hiroshi

AU - Hatakeyama, Susumi

PY - 1998/1/1

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AB - Successive treatment of 1-trimethylsilyl-2.3-butadienes with iodine and tetra-n-butylammonium fluoride in the same flask affords 2-iodo-1.3- butadienes in good yields and their palladium-catalyzed carbonylation and alkynylation allows introduction of ester and alkynyl groups to the 2- position bearing an iodine atom leading to various 2.3-disubstituted 1,3- butadienes.

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Preparation of 2-iodo-1,3-butadienes from 1-trimethylsilyl-2,3- butadienes and their functionalizations

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