TY - JOUR
T1 - Preparation of bioactive spherical particles in the CaO-SiO2 system through sol-gel processing under coexistence of poly(ethylene glycol)
AU - Kim, Ill Yong
AU - Kawachi, Giichiro
AU - Kikuta, Koichi
AU - Cho, Sung Baek
AU - Kamitakahara, Masanobu
AU - Ohtsuki, Chikara
PY - 2008/1/7
Y1 - 2008/1/7
N2 - Glasses in CaO-SiO2 system provide bioactive materials that achieve direct bonding to living bone. In the development of bioactive organic-inorganic composites, CaO-SiO2 particles with controlled size and morphology are expected to be useful as inorganic fillers. Our previous study showed that sol-gel processing of tetraethoxysilane (TEOS) and calcium nitrate tetrahydrate (CNT, Ca(NO3)2·4H2O) in the presence of poly(ethylene glycol) (PEG) can produce bioactive CaO-SiO2 spherical particles. However, the detailed conditions for preparing the particles with controlled morphology have not been revealed. In the present study, we investigated relationships between starting composition, specifically the weight ratios of TEOS, CNT and PEG, and morphology of the obtained gels. Aggregation of spherical particles was obtained when PEG was added, and the size of particles decreased from micro- to nano-sized with increasing amounts of PEG. Within 1 day of soaking in a simulated body fluid (SBF) a bone-like apatite layer was formed on the surface of all gels starting from the molar ratio of CNT/TEOS = 3/7 (which is assumed to be 30CaO·70SiO2), followed by heat treatment at 600 °C.
AB - Glasses in CaO-SiO2 system provide bioactive materials that achieve direct bonding to living bone. In the development of bioactive organic-inorganic composites, CaO-SiO2 particles with controlled size and morphology are expected to be useful as inorganic fillers. Our previous study showed that sol-gel processing of tetraethoxysilane (TEOS) and calcium nitrate tetrahydrate (CNT, Ca(NO3)2·4H2O) in the presence of poly(ethylene glycol) (PEG) can produce bioactive CaO-SiO2 spherical particles. However, the detailed conditions for preparing the particles with controlled morphology have not been revealed. In the present study, we investigated relationships between starting composition, specifically the weight ratios of TEOS, CNT and PEG, and morphology of the obtained gels. Aggregation of spherical particles was obtained when PEG was added, and the size of particles decreased from micro- to nano-sized with increasing amounts of PEG. Within 1 day of soaking in a simulated body fluid (SBF) a bone-like apatite layer was formed on the surface of all gels starting from the molar ratio of CNT/TEOS = 3/7 (which is assumed to be 30CaO·70SiO2), followed by heat treatment at 600 °C.
KW - Biomedical application
KW - CaO-SiO
KW - Microstructure-final
KW - Sol-gel processes
UR - http://www.scopus.com/inward/record.url?scp=41249086139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41249086139&partnerID=8YFLogxK
U2 - 10.1016/j.jeurceramsoc.2007.11.006
DO - 10.1016/j.jeurceramsoc.2007.11.006
M3 - Article
AN - SCOPUS:41249086139
SN - 0955-2219
VL - 28
SP - 1595
EP - 1602
JO - Journal of the European Ceramic Society
JF - Journal of the European Ceramic Society
IS - 8
ER -