Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.
|Number of pages||2|
|Journal||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|Publication status||Published - 1999 Mar|
|Event||Proceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA|
Duration: 1999 Mar 21 → 1999 Mar 25