Preparation of blood compatible nanoparticles bearing phosphorylcholine group

Kazuhiko Ishihara, Tomohiro Konno, Kimio Kurita, Yasuhiko Iwasaki, Nobuo Nakabayashi

Research output: Contribution to journalConference articlepeer-review


Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.

Original languageEnglish
Pages (from-to)283-284
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Issue number1
Publication statusPublished - 1999 Mar
EventProceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA
Duration: 1999 Mar 211999 Mar 25


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