Preparation of granules of calcium deficient hydroxyapatite composed of rod-shaped particles and evaluation of their potential for drug carrier

Masanobu Kamitakahara; Kiyoko Sato; Ryosuke Fujii; Ryohei Imai; Koji Ioku

Preparation of granules of calcium deficient hydroxyapatite composed of rod-shaped particles and evaluation of their potential for drug carrier

Masanobu Kamitakahara, Kiyoko Sato, Ryosuke Fujii, Ryohei Imai, Koji Ioku

ENV - Environmental Studies for Advanced Society

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A combination of a material which is included bone metabolism and a drug to moderate the metabolism is promising for bone regeneration. Spherical granules of rod-shaped hydroxyapatite (HA) were prepared through the hydrothermal process. The size of the granules were about 1 mm in diameter. Their Ca/P molar ratio was 1.61 and this indicates that their composition was not stoichiometric (1.67) but Ca-deficient. Their adsorption ability for tetrahydrocurcumin (THC), which inhibited the proliferation of osteoblast-like cells and show the possibility for pharmacological effect, was revealed. The HA granules with THC has a potential to show the pharmacological effect, accompanied by the resorption of the HA granules according to bone metabolism.

Original language	English
Pages (from-to)	28-31
Number of pages	4
Journal	Journal of the Australian Ceramic Society
Volume	47
Issue number	1
Publication status	Published - 2011

Keywords

Adsorption
Bone
Drug carrier
Hydrothermal process
Hydroxyapatite
Tetrahydrocurcumin

Cite this

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AU - Kamitakahara, Masanobu

AU - Sato, Kiyoko

AU - Fujii, Ryosuke

AU - Imai, Ryohei

AU - Ioku, Koji

PY - 2011

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N2 - A combination of a material which is included bone metabolism and a drug to moderate the metabolism is promising for bone regeneration. Spherical granules of rod-shaped hydroxyapatite (HA) were prepared through the hydrothermal process. The size of the granules were about 1 mm in diameter. Their Ca/P molar ratio was 1.61 and this indicates that their composition was not stoichiometric (1.67) but Ca-deficient. Their adsorption ability for tetrahydrocurcumin (THC), which inhibited the proliferation of osteoblast-like cells and show the possibility for pharmacological effect, was revealed. The HA granules with THC has a potential to show the pharmacological effect, accompanied by the resorption of the HA granules according to bone metabolism.

AB - A combination of a material which is included bone metabolism and a drug to moderate the metabolism is promising for bone regeneration. Spherical granules of rod-shaped hydroxyapatite (HA) were prepared through the hydrothermal process. The size of the granules were about 1 mm in diameter. Their Ca/P molar ratio was 1.61 and this indicates that their composition was not stoichiometric (1.67) but Ca-deficient. Their adsorption ability for tetrahydrocurcumin (THC), which inhibited the proliferation of osteoblast-like cells and show the possibility for pharmacological effect, was revealed. The HA granules with THC has a potential to show the pharmacological effect, accompanied by the resorption of the HA granules according to bone metabolism.

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KW - Bone

KW - Drug carrier

KW - Hydrothermal process

KW - Hydroxyapatite

KW - Tetrahydrocurcumin

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Preparation of granules of calcium deficient hydroxyapatite composed of rod-shaped particles and evaluation of their potential for drug carrier

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