Preparation of magnetite aqueous dispersion for magnetic fluid hyperthermia

Teppei Kikuchi, Ryo Kasuya, Shota Endo, Akira Nakamura, Toshiyuki Takai, Nils Metzler-Nolte, Kazuyuki Tohji, Jeyadevan Balachandran

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated monodispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac)3) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magnetite nanoparticles varied between 5 and 12 nm depending on the experimental parameters such as reaction temperature, metal salt concentration and oleic acid/oleylamine ratio. Though the as-synthesized particles were coated with oleate and were dispersible in organic solvent, their surfaces were modified using amphiphilic co-polymers composed of poly(maleic anhydride-alt-1-octadecene) and polyethylene glycol-methyl ether and made dispersible in water. Infrared spectra of the sample indicated the existence of -COOH groups on the surface for further conjugation with biomolecules for targeted cancer therapy.

Original languageEnglish
Pages (from-to)1216-1222
Number of pages7
JournalJournal of Magnetism and Magnetic Materials
Issue number10
Publication statusPublished - 2011 May


  • Magnetic fluid hyperthermia
  • Surface modification
  • Thermal decomposition


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