TY - JOUR
T1 - Preparation of magnetite aqueous dispersion for magnetic fluid hyperthermia
AU - Kikuchi, Teppei
AU - Kasuya, Ryo
AU - Endo, Shota
AU - Nakamura, Akira
AU - Takai, Toshiyuki
AU - Metzler-Nolte, Nils
AU - Tohji, Kazuyuki
AU - Balachandran, Jeyadevan
PY - 2011/5
Y1 - 2011/5
N2 - An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated monodispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac)3) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magnetite nanoparticles varied between 5 and 12 nm depending on the experimental parameters such as reaction temperature, metal salt concentration and oleic acid/oleylamine ratio. Though the as-synthesized particles were coated with oleate and were dispersible in organic solvent, their surfaces were modified using amphiphilic co-polymers composed of poly(maleic anhydride-alt-1-octadecene) and polyethylene glycol-methyl ether and made dispersible in water. Infrared spectra of the sample indicated the existence of -COOH groups on the surface for further conjugation with biomolecules for targeted cancer therapy.
AB - An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated monodispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac)3) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magnetite nanoparticles varied between 5 and 12 nm depending on the experimental parameters such as reaction temperature, metal salt concentration and oleic acid/oleylamine ratio. Though the as-synthesized particles were coated with oleate and were dispersible in organic solvent, their surfaces were modified using amphiphilic co-polymers composed of poly(maleic anhydride-alt-1-octadecene) and polyethylene glycol-methyl ether and made dispersible in water. Infrared spectra of the sample indicated the existence of -COOH groups on the surface for further conjugation with biomolecules for targeted cancer therapy.
KW - Magnetic fluid hyperthermia
KW - Surface modification
KW - Thermal decomposition
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UR - http://www.scopus.com/inward/citedby.url?scp=79952194061&partnerID=8YFLogxK
U2 - 10.1016/j.jmmm.2010.11.009
DO - 10.1016/j.jmmm.2010.11.009
M3 - Article
AN - SCOPUS:79952194061
SN - 0304-8853
VL - 323
SP - 1216
EP - 1222
JO - Journal of Magnetism and Magnetic Materials
JF - Journal of Magnetism and Magnetic Materials
IS - 10
ER -
