Preparation of multilayered silica-Gd-silica core-shell particles and their magnetic resonance images

Yoshio Kobayashi; Junichi Imai; Daisuke Nagao; Motohiro Takeda; Noriaki Ohuchi; Atsuo Kasuya; Mikio Konno

doi:10.1016/j.colsurfa.2007.05.024

Preparation of multilayered silica-Gd-silica core-shell particles and their magnetic resonance images

Yoshio Kobayashi, Junichi Imai, Daisuke Nagao, Motohiro Takeda, Noriaki Ohuchi, Atsuo Kasuya, Mikio Konno

ENG - Chemical Engineering

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

A preparation method for multilayered silica-Gd-silica core-shell particles is proposed. Silica particles with an average size of 30.9 nm were prepared by the Stöber method. Silica-Gd core-shell particles with a size of 57.4 nm were synthesized by a homogeneous precipitation method at 80 °C in water/propanol solution with 27.7 M H₂O, 0.001 M Gd(NO₃)₃, 0.5 M urea and 1 g/l polyvinylpyrrolidone in the presence of 0.001 vol.% suspension of the silica particles. Succeeding silica-coating of the silica-Gd core-shell particles was performed with 0.0133 M TEOS and 0.002 M NaOH in the presence of a suspension of silica-Gd core-shell particles. Consequently, multilayered silica-Gd-silica core-shell particles with an average size of 71.2 nm could be obtained. These particles exhibited clear enhancement in magnetic resonance images. These nanoparticles are expected to a novel magnetic resonance contrast agents.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	308
Issue number	1-3
DOIs	https://doi.org/10.1016/j.colsurfa.2007.05.024
Publication status	Published - 2007 Oct 31

Keywords

Core-shell
Gadolinium
Homogeneous precipitation method
MRI
Multilayer
Particle
Silica
Stöber method

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10.1016/j.colsurfa.2007.05.024

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title = "Preparation of multilayered silica-Gd-silica core-shell particles and their magnetic resonance images",

abstract = "A preparation method for multilayered silica-Gd-silica core-shell particles is proposed. Silica particles with an average size of 30.9 nm were prepared by the St{\"o}ber method. Silica-Gd core-shell particles with a size of 57.4 nm were synthesized by a homogeneous precipitation method at 80 °C in water/propanol solution with 27.7 M H2O, 0.001 M Gd(NO3)3, 0.5 M urea and 1 g/l polyvinylpyrrolidone in the presence of 0.001 vol.% suspension of the silica particles. Succeeding silica-coating of the silica-Gd core-shell particles was performed with 0.0133 M TEOS and 0.002 M NaOH in the presence of a suspension of silica-Gd core-shell particles. Consequently, multilayered silica-Gd-silica core-shell particles with an average size of 71.2 nm could be obtained. These particles exhibited clear enhancement in magnetic resonance images. These nanoparticles are expected to a novel magnetic resonance contrast agents.",

keywords = "Core-shell, Gadolinium, Homogeneous precipitation method, MRI, Multilayer, Particle, Silica, St{\"o}ber method",

author = "Yoshio Kobayashi and Junichi Imai and Daisuke Nagao and Motohiro Takeda and Noriaki Ohuchi and Atsuo Kasuya and Mikio Konno",

note = "Funding Information: This research was partially supported by the Ministry of Education of Japan, Culture, Sports, Science and Technology, a Grant-in-Aid for the COE project, Giant Molecules and Complex Systems and the Center for Interdisciplinary Research of Tohoku University.",

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AU - Kobayashi, Yoshio

AU - Imai, Junichi

AU - Nagao, Daisuke

AU - Takeda, Motohiro

AU - Ohuchi, Noriaki

AU - Kasuya, Atsuo

AU - Konno, Mikio

N1 - Funding Information: This research was partially supported by the Ministry of Education of Japan, Culture, Sports, Science and Technology, a Grant-in-Aid for the COE project, Giant Molecules and Complex Systems and the Center for Interdisciplinary Research of Tohoku University.

PY - 2007/10/31

Y1 - 2007/10/31

N2 - A preparation method for multilayered silica-Gd-silica core-shell particles is proposed. Silica particles with an average size of 30.9 nm were prepared by the Stöber method. Silica-Gd core-shell particles with a size of 57.4 nm were synthesized by a homogeneous precipitation method at 80 °C in water/propanol solution with 27.7 M H2O, 0.001 M Gd(NO3)3, 0.5 M urea and 1 g/l polyvinylpyrrolidone in the presence of 0.001 vol.% suspension of the silica particles. Succeeding silica-coating of the silica-Gd core-shell particles was performed with 0.0133 M TEOS and 0.002 M NaOH in the presence of a suspension of silica-Gd core-shell particles. Consequently, multilayered silica-Gd-silica core-shell particles with an average size of 71.2 nm could be obtained. These particles exhibited clear enhancement in magnetic resonance images. These nanoparticles are expected to a novel magnetic resonance contrast agents.

AB - A preparation method for multilayered silica-Gd-silica core-shell particles is proposed. Silica particles with an average size of 30.9 nm were prepared by the Stöber method. Silica-Gd core-shell particles with a size of 57.4 nm were synthesized by a homogeneous precipitation method at 80 °C in water/propanol solution with 27.7 M H2O, 0.001 M Gd(NO3)3, 0.5 M urea and 1 g/l polyvinylpyrrolidone in the presence of 0.001 vol.% suspension of the silica particles. Succeeding silica-coating of the silica-Gd core-shell particles was performed with 0.0133 M TEOS and 0.002 M NaOH in the presence of a suspension of silica-Gd core-shell particles. Consequently, multilayered silica-Gd-silica core-shell particles with an average size of 71.2 nm could be obtained. These particles exhibited clear enhancement in magnetic resonance images. These nanoparticles are expected to a novel magnetic resonance contrast agents.

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Preparation of multilayered silica-Gd-silica core-shell particles and their magnetic resonance images

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Keywords

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