Preparation of multilayered silica-Gd-silica core-shell particles and their magnetic resonance images

Yoshio Kobayashi, Junichi Imai, Daisuke Nagao, Motohiro Takeda, Noriaki Ohuchi, Atsuo Kasuya, Mikio Konno

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33 Citations (Scopus)


A preparation method for multilayered silica-Gd-silica core-shell particles is proposed. Silica particles with an average size of 30.9 nm were prepared by the Stöber method. Silica-Gd core-shell particles with a size of 57.4 nm were synthesized by a homogeneous precipitation method at 80 °C in water/propanol solution with 27.7 M H2O, 0.001 M Gd(NO3)3, 0.5 M urea and 1 g/l polyvinylpyrrolidone in the presence of 0.001 vol.% suspension of the silica particles. Succeeding silica-coating of the silica-Gd core-shell particles was performed with 0.0133 M TEOS and 0.002 M NaOH in the presence of a suspension of silica-Gd core-shell particles. Consequently, multilayered silica-Gd-silica core-shell particles with an average size of 71.2 nm could be obtained. These particles exhibited clear enhancement in magnetic resonance images. These nanoparticles are expected to a novel magnetic resonance contrast agents.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Issue number1-3
Publication statusPublished - 2007 Oct 31


  • Core-shell
  • Gadolinium
  • Homogeneous precipitation method
  • MRI
  • Multilayer
  • Particle
  • Silica
  • Stöber method


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