TY - JOUR
T1 - Preparation of porous yttrium oxide microparticles by gelation of ammonium alginate in aqueous solution containing yttrium ions
AU - Kawashita, Masakazu
AU - Matsui, Naoko
AU - Li, Zhixia
AU - Miyazaki, Toshiki
N1 - Funding Information:
Acknowledgments This work was partially supported by Funds for Promoting Science and Technology under the Program for Exploring Advanced Interdisciplinary Frontiers, the Ministry of Education, Culture, Sports, Science and Technology, Japan, and Research Grant, Japan Bioindustry Association, Japan. The authors thank to Mr. Yokoi and Prof. Ohtsuki, Graduate School of Engineering, Nagoya University, for ICP measurement of samples, and Dr. Maeda, Graduate School of Environmental Science, Tohoku University, for porosity measurement of samples.
PY - 2010/6
Y1 - 2010/6
N2 - Porous Y2O3 microparticles 500 μm in size were obtained, when 1 wt%-ammonium alginate aqueous solution was dropped into 0.5 M-YCl3 aqueous solution by a Pasteur pipette and the resultant gel microparticles were heat-treated at 1100°C. Small pores less than 1 μm were formed in the microparticles by the heat treatment. The bulk density of the heat-treated microparticle was as low as 0.66 g cm-3. The chemical durability of the heat-treated microparticles in simulated body fluid at pH = 6 and 7 was high enough for clinical application of in situ radiotherapy. Although the size of the microparticles should be decreased to around 25 μm using atomizing device such as spray gun for clinical application, we found that the porous Y2O3 microparticles with high chemical durability and low density can be obtained by utilizing gelation of ammonium alginate in YCl3 aqueous solution in this study.
AB - Porous Y2O3 microparticles 500 μm in size were obtained, when 1 wt%-ammonium alginate aqueous solution was dropped into 0.5 M-YCl3 aqueous solution by a Pasteur pipette and the resultant gel microparticles were heat-treated at 1100°C. Small pores less than 1 μm were formed in the microparticles by the heat treatment. The bulk density of the heat-treated microparticle was as low as 0.66 g cm-3. The chemical durability of the heat-treated microparticles in simulated body fluid at pH = 6 and 7 was high enough for clinical application of in situ radiotherapy. Although the size of the microparticles should be decreased to around 25 μm using atomizing device such as spray gun for clinical application, we found that the porous Y2O3 microparticles with high chemical durability and low density can be obtained by utilizing gelation of ammonium alginate in YCl3 aqueous solution in this study.
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U2 - 10.1007/s10856-010-4050-4
DO - 10.1007/s10856-010-4050-4
M3 - Article
C2 - 20232233
AN - SCOPUS:77954534671
SN - 0957-4530
VL - 21
SP - 1837
EP - 1843
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 6
ER -