Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy

Masakazu Kawashita; Naoko Matsui; Zhixia Li; Toshiki Miyazaki; Hiroyasu Kanetaka

doi:10.1002/jbm.b.31870

Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy

Masakazu Kawashita, Naoko Matsui, Zhixia Li, Toshiki Miyazaki, Hiroyasu Kanetaka

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In this study, we attempted to prepare yttrium phosphate (YPO ₄) microspheres with high chemical durability. YPO ₄ microspheres with smooth surfaces and diameters of around 25 μm were successfully obtained when gelatin droplets containing yttrium and phosphate ions were cooled and solidified in a water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in a simulated body fluid at pH = 6 and 7 was high enough for clinical application of intra-arterial radiotherapy.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	99 B
Issue number	1
DOIs	https://doi.org/10.1002/jbm.b.31870
Publication status	Published - 2011 Oct

Keywords

chemical durability
intra-arterial radiotherapy
microspheres
yttrium phosphate

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AU - Miyazaki, Toshiki

AU - Kanetaka, Hiroyasu

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Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy

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