Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

Kazuhiro Takahashi; Masahiko Sone; Fumitoshi Satoh; Osamu Murakami; Kazuhito Totsune; Hiroaki Tanji; Nobuyuki Sato; Hisao Ito; Toraichi Mouri

doi:10.1016/S0196-9781(96)00328-2

Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

Kazuhiro Takahashi, Masahiko Sone, Fumitoshi Satoh, Osamu Murakami, Kazuhito Totsune, Hiroaki Tanji, Nobuyuki Sato, Hisao Ito, Toraichi Mouri

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.

Original language	English
Pages (from-to)	459-461
Number of pages	3
Journal	Peptides
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/S0196-9781(96)00328-2
Publication status	Published - 1997

Keywords

Adrenomedullin
Cerebrospinal fluid
Choroid plexus
Chromatography
Radioimmunoassay

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0196-9781(96)00328-2

Cite this

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title = "Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid",

abstract = "The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.",

keywords = "Adrenomedullin, Cerebrospinal fluid, Choroid plexus, Chromatography, Radioimmunoassay",

author = "Kazuhiro Takahashi and Masahiko Sone and Fumitoshi Satoh and Osamu Murakami and Kazuhito Totsune and Hiroaki Tanji and Nobuyuki Sato and Hisao Ito and Toraichi Mouri",

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doi = "10.1016/S0196-9781(96)00328-2",

language = "English",

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T1 - Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

AU - Takahashi, Kazuhiro

AU - Sone, Masahiko

AU - Satoh, Fumitoshi

AU - Murakami, Osamu

AU - Totsune, Kazuhito

AU - Tanji, Hiroaki

AU - Sato, Nobuyuki

AU - Ito, Hisao

AU - Mouri, Toraichi

PY - 1997

Y1 - 1997

N2 - The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.

AB - The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.

KW - Adrenomedullin

KW - Cerebrospinal fluid

KW - Choroid plexus

KW - Chromatography

KW - Radioimmunoassay

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JO - Peptides

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Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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