TY - JOUR
T1 - Presence of multiple copies of capsulation loci in invasive Haemophilus influenzae type b (Hib) strains in Japan before introduction of the Hib conjugate vaccine
AU - Ueno, Kentaro
AU - Nishi, Junichiro
AU - Imuta, Naoko
AU - Tokuda, Koichi
AU - Kawano, Yoshifumi
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Despite the effectiveness of the Hib vaccine, multiple amplification of the capb locus contributes to vaccine failure. However, there has been no report on the effect of Hib locus amplification in Japan. We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern blot analysis showed that four strains (16.7%) harbored multiple copies (more than two) of the capb locus. Careful analysis of the locus in circulating Hib strains is necessary now that the Hib vaccine has been introduced into Japan.
AB - Despite the effectiveness of the Hib vaccine, multiple amplification of the capb locus contributes to vaccine failure. However, there has been no report on the effect of Hib locus amplification in Japan. We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern blot analysis showed that four strains (16.7%) harbored multiple copies (more than two) of the capb locus. Careful analysis of the locus in circulating Hib strains is necessary now that the Hib vaccine has been introduced into Japan.
KW - Capsular polysaccharide
KW - Haemophilus influenzae type b
KW - Hib conjugate vaccine
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U2 - 10.1111/j.1348-0421.2010.00196.x
DO - 10.1111/j.1348-0421.2010.00196.x
M3 - Article
C2 - 20236426
AN - SCOPUS:77649298307
SN - 0385-5600
VL - 54
SP - 160
EP - 163
JO - Microbiology and Immunology
JF - Microbiology and Immunology
IS - 3
ER -
