Prevention of tissue adhesion by a spontaneously formed phospholipid polymer hydrogel

Mizuna Kimura, Tomohiro Konno, Madoka Takai, Noriyuki Ishiyama, Toru Moro, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We investigated phospholipid polymer hydrogels containing Fe3+ ions (PMA/PMB/Fe hydrogel) for their use as antiadhesive materials in the healing tissues. These hydrogels were prepared from the aqueous solutions of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-methacrylic acid) (PMA) and poly(MPC-co-n-butyl methacrylate) (PMB). The PMA/PMB hydrogel is formed by the intermolecular interactions between PMA and PMB, and it reversibly dissociates under physiological conditions. The addition of Fe3+ ions could control the gelation time and the dissociation time. Mechanical properties such as the gelation time and viscoelastic properties can be controlled by the FeCL3 concentration. With regard to biocompatibility, no evidence of inflammation was observed in vivo. Therefore, the PMA/PMB/Fe hydrogel has a potential to be used as an antiadhesive material.

Original languageEnglish
Pages (from-to)777-780
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2007


  • Antiadhesion
  • Biocompatibility
  • Hydrogel
  • Phospholipid polymers
  • Tissue healing


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