Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review

Satoshi Ichikawa; Kei Saito; Noriko Fukuhara; Hisayuki Yokoyama; Koichi Onodera; Yasushi Onishi; Ryo Ichinohasama; Hideo Harigae

doi:10.1016/j.lrr.2020.100223

Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review

Satoshi Ichikawa, Kei Saito, Noriko Fukuhara, Hisayuki Yokoyama, Koichi Onodera, Yasushi Onishi, Ryo Ichinohasama, Hideo Harigae

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of L-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.

Original language	English
Article number	100223
Journal	Leukemia Research Reports
Volume	14
DOIs	https://doi.org/10.1016/j.lrr.2020.100223
Publication status	Published - 2020

Keywords

Allogeneic hematopoietic stem cell transplantation
Graft-versus-lymphoma effect
L-asparaginase
Primary adrenal extranodal NK/T-cell lymphoma
lymphomatous meningitis

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2020.100223

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title = "Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review",

abstract = "A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of L-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.",

keywords = "Allogeneic hematopoietic stem cell transplantation, Graft-versus-lymphoma effect, L-asparaginase, Primary adrenal extranodal NK/T-cell lymphoma, lymphomatous meningitis",

author = "Satoshi Ichikawa and Kei Saito and Noriko Fukuhara and Hisayuki Yokoyama and Koichi Onodera and Yasushi Onishi and Ryo Ichinohasama and Hideo Harigae",

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year = "2020",

doi = "10.1016/j.lrr.2020.100223",

language = "English",

volume = "14",

journal = "Leukemia Research Reports",

issn = "2213-0489",

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T1 - Primary adrenal extranodal NK/T-cell lymphoma

T2 - A case report and literature review

AU - Ichikawa, Satoshi

AU - Saito, Kei

AU - Fukuhara, Noriko

AU - Yokoyama, Hisayuki

AU - Onodera, Koichi

AU - Onishi, Yasushi

AU - Ichinohasama, Ryo

AU - Harigae, Hideo

PY - 2020

Y1 - 2020

N2 - A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of L-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.

AB - A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of L-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Graft-versus-lymphoma effect

KW - L-asparaginase

KW - Primary adrenal extranodal NK/T-cell lymphoma

KW - lymphomatous meningitis

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JO - Leukemia Research Reports

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ER -

Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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