Primary ependymoma of the ovary: A case report and literature review

T. Takano, Jun Ichi Akahira, T. Moriya, T. Murakami, M. Tanaka, M. Goto, H. Niikura, K. Ito, Y. Mikami, K. Okamura, N. Yaegashi

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Ependymoma is a glioma with differentiation toward ependymal cells that usually arises in the central nervous system. Ovarian ependymoma is extremely rare, and the treatment strategies for this disease have not been established. This is the first report of a patient with advanced ovarian ependymoma who received fertility-sparing surgery and is now alive without disease. A 23-year-old Japanese woman, gravida 0, presented with a chief complaint of lower abdominal distension and weight loss. She underwent left salpingo-oophorectomy for suspected ovarian cancer. Microscopic examination revealed a highly cellular tumor composed of small cells with hyperchromatic, round-to-oval nuclei and scanty cytoplasm. Perivascular pseudorosettes, ependymal rosettes, and extensive necrosis were observed. After thorough pathologic examination, she was diagnosed as having stage IIIC ovarian ependymoma. Postoperatively, she received adjuvant chemotherapy and underwent secondary cytoreductive surgery that preserved the uterus and right ovary. Her menstrual cycle has resumed, and she is alive without evidence of disease 16 months after the start of treatment. Although rare, primary ovarian ependymoma must be kept in mind in the differential diagnosis of ovarian tumors, especially in young women. Administration of etoposide-based chemotherapy along with cytoreductive surgery is a potential standard treatment for advanced ovarian ependymoma.

Original languageEnglish
Pages (from-to)1138-1141
Number of pages4
JournalInternational Journal of Gynecological Cancer
Issue number6
Publication statusPublished - 2005 Nov


  • BEP chemotherapy
  • Ependymoma
  • Germ cell tumor
  • Ovary

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology


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