Primary osteosarcoma of the uterine cervix is extremely rare. Only 20 cases have been reported, 19 of which originated in the uterine corpus. We report a case of primary uterine cervical osteosarcoma with pulmonary metastasis in a 30-year-old nulligravida woman. The initial diagnosis was carcinosarcoma of the uterine cervix, as detected by cervical cytology and biopsy analysis. We performed a total hysterectomy, bilateral salpingo-oophorectomy and colostomy without macroscopic residual tumors in the abdominal cavity, but pelvic recurrent tumors appeared 14 days postoperatively. Both recurrent and metastatic tumors were effectively reduced by combination therapy of adriamycin with ifosfamide; however, the patient died as a result of of disease progression nine months after her first visit to our department.
- Clinicopathological features
- osteosarcoma of the uterine cervix