Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies

Isamu Akiba, Tai Kubo, Akito Maeda, Hideaki Bujo, Junichi Nakai, Masayoshi Mishina, Shosaku Numa

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

The complete amino acid sequence of porcine muscarinic acetylcholine receptor III has been deduced by cloning and sequencing the genomic DNA. The antagonist binding properties of muscarinic acetylcholine receptor III expressed from the cloned DNA in Xenopus oocytes correspond most closely to those of the pharmacologically defined M2 glandular (III) subtype.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalFEBS Letters
Volume235
Issue number1-2
DOIs
Publication statusPublished - 1988 Aug 1

Keywords

  • (Xenopus oocyte)
  • DNA expression
  • genomic DNA cloning
  • Muscarinic acetylcholine receptor subtype
  • Nucleotide sequence
  • Selective antagonist

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