Primary vaginal adenosarcoma with sarcomatous overgrowth

Masafumi Toyoshima, Jun Ichi Akahira, Takuya Moriya, Seiichirou Hayakawa, Nobuo Yaegashi

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9 Citations (Scopus)


Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis. A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery. Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.

Original languageEnglish
Pages (from-to)759-761
Number of pages3
JournalGynecologic Oncology
Issue number3
Publication statusPublished - 2004 Dec


  • Case report
  • Mullerian adenosarcoma
  • Sarcomatous overgrowth
  • Vaginal tumor

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology


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