Production of Auger-electron-emitting ^103mRh via a ¹⁰³Pd/^103mRh generator using an anion-exchange resin

Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of 103mRh is relatively short (56.114min). Therefore, it needs to be produced using a generator for clinical use. Most studies of 103Pd/103mRh generators using anion-exchange resins were carried out over 50years ago. However, these resins are no longer commercially available. In the present study, we tested a 103Pd/103mRh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added 103Pd was used to make the generators. The 103mRh product was eluted from the generators using 6mL of 0.1M HCl with a flow rate 0.5mL/min. The generator made from SA11AL showed good performance, with a yield of 39%, an impurity level of 103Pd in the product of 0.29%, and an operation time of 14min. This makes this generator competitive with previously developed ones.