TY - JOUR
T1 - Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish
AU - Yotsu, Mari
AU - Yamazaki, Tomoko
AU - Meguro, Yuko
AU - Endo, Amane
AU - Murata, Michio
AU - Naoki, Hideo
AU - Yasumoto, Takeshi
N1 - Funding Information:
Acknowledgenrart .-The study wag supported in part by a Grant-in-Aid for Scientific l3esearch from the Ministry of Education, Scieaa and Culture of Japan.
PY - 1987
Y1 - 1987
N2 - Bacteria isolated from the skin of the pufferfish Fugu poecilonotus were screened for tetrodotoxin production. Tetrodotoxin and its derivatives were detected by HPLC analyses in broth cultures of a Pseudomonas sp. Upon alkali treatment the compounds yielded, as do tetrodotoxin and its derivatives, 2-amino-6-hydroxymethyl-8-hydroxyquinazoline, the identity of which was confirmed, after methylation or trimethylsilylation, by HPLC, mass spectrometry and gas chromatography - mass spectrometry.
AB - Bacteria isolated from the skin of the pufferfish Fugu poecilonotus were screened for tetrodotoxin production. Tetrodotoxin and its derivatives were detected by HPLC analyses in broth cultures of a Pseudomonas sp. Upon alkali treatment the compounds yielded, as do tetrodotoxin and its derivatives, 2-amino-6-hydroxymethyl-8-hydroxyquinazoline, the identity of which was confirmed, after methylation or trimethylsilylation, by HPLC, mass spectrometry and gas chromatography - mass spectrometry.
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U2 - 10.1016/0041-0101(87)90245-5
DO - 10.1016/0041-0101(87)90245-5
M3 - Article
C2 - 3576639
AN - SCOPUS:0023096321
SN - 0041-0101
VL - 25
SP - 225
EP - 228
JO - Toxicon
JF - Toxicon
IS - 2
ER -