Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression

Sadanori Furudate; Taku Fujimura; Akira Tsukada; Yukikazu Numata; Yumi Kambayashi; Setsuya Aiba

doi:10.1159/000343881

Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression

Sadanori Furudate, Taku Fujimura, Akira Tsukada, Yukikazu Numata, Yumi Kambayashi, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	Case Reports in Dermatology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1159/000343881
Publication status	Published - 2012 Apr 20

Keywords

Granulysin
Spontaneous regression
Trichilemmal carcinoma

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10.1159/000343881

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abstract = "We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.",

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AU - Furudate, Sadanori

AU - Fujimura, Taku

AU - Tsukada, Akira

AU - Numata, Yukikazu

AU - Kambayashi, Yumi

AU - Aiba, Setsuya

PY - 2012/4/20

Y1 - 2012/4/20

N2 - We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.

AB - We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.

KW - Granulysin

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Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression

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