Progesterone receptor subtypes in vascular smooth muscle cells of human aorta

Yasuhiro Nakamura; Takashi Suzuki; Tsukasa Inoue; Chika Tazawa; Katsuhiko Ono; Takuya Moriya; Haruo Saito; Tadashi Ishibashi; Shoki Takahashi; Shogo Yamada; Hironobu Sasano

doi:10.1507/endocrj.52.245

Progesterone receptor subtypes in vascular smooth muscle cells of human aorta

Yasuhiro Nakamura, Takashi Suzuki, Tsukasa Inoue, Chika Tazawa, Katsuhiko Ono, Takuya Moriya, Haruo Saito, Tadashi Ishibashi, Shoki Takahashi, Shogo Yamada, Hironobu Sasano

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Progesterone is involved in various functions of the cardiovascular system, including those of vascular smooth muscle cells (VSMCs) via progesterone receptor (PR). Progesterone has also been postulated to be involved in inhibition of VSMC proliferation via PR. However, the details of PR expression have remained largely unknown in human cardiovascular VSMCs. Therefore, we first examined the relative levels of PR isoform (PR-A and PR-B) expression in VSMCs, using both immunohistochemistry and quantitative RT-PCR analysis. PR-B was equally expressed between male and female aorta, but PR-A was more abundant in female than in male aorta. This finding demonstrated that the status of PR subtype expression was associated with the difference of genders.

Original language	English
Pages (from-to)	245-252
Number of pages	8
Journal	Endocrine Journal
Volume	52
Issue number	2
DOIs	https://doi.org/10.1507/endocrj.52.245
Publication status	Published - 2005 Apr

Keywords

Human aorta
Immunohistochemistry
Progesterone receptor
RT/real-time PCR
Vascular smooth muscle cells

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1507/endocrj.52.245

Cite this

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abstract = "Progesterone is involved in various functions of the cardiovascular system, including those of vascular smooth muscle cells (VSMCs) via progesterone receptor (PR). Progesterone has also been postulated to be involved in inhibition of VSMC proliferation via PR. However, the details of PR expression have remained largely unknown in human cardiovascular VSMCs. Therefore, we first examined the relative levels of PR isoform (PR-A and PR-B) expression in VSMCs, using both immunohistochemistry and quantitative RT-PCR analysis. PR-B was equally expressed between male and female aorta, but PR-A was more abundant in female than in male aorta. This finding demonstrated that the status of PR subtype expression was associated with the difference of genders.",

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AU - Nakamura, Yasuhiro

AU - Suzuki, Takashi

AU - Inoue, Tsukasa

AU - Tazawa, Chika

AU - Ono, Katsuhiko

AU - Moriya, Takuya

AU - Saito, Haruo

AU - Ishibashi, Tadashi

AU - Takahashi, Shoki

AU - Yamada, Shogo

AU - Sasano, Hironobu

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KW - Immunohistochemistry

KW - Progesterone receptor

KW - RT/real-time PCR

KW - Vascular smooth muscle cells

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Progesterone receptor subtypes in vascular smooth muscle cells of human aorta

Abstract

Keywords

UN SDGs

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