Prognostic relevance of rosette-like features in osteosarcoma

K. Okada, T. Hasegawa, R. Yokoyama, Y. Beppu, E. Itoi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Aims: To clarify the prognostic relevance of rosette-like features and other clinicopathological and immunohistochemical variables in patients with osteosarcoma. Methods: Clinicopathological and immunohistochemical variables were analysed in 131 patients with non-metastatic high grade conventional osteosarcoma, with particular attention to the prognostic impact of rosette-like features. Results: Rosette-like features were present in 18 (14%) cases. Rosette-like features were significantly associated with the osteoblastic subtype, numerous osteoclast-like giant cells, moderate pleomorphism, frequent haemangiopericytoma-like vascular patterns, epithelioid cytological features, positive immunoreactivity for epithelial membrane antigen and CD56, and negative staining for cytokeratin. In a multivariate analysis, rosette-like features (relative risk (RR), 3.8), a poor chemotherapy effect (RR, 2.9), and a tumour size of 10 cm or more (RR, 2.8) were identified as unfavourable prognostic factors. Conclusions: Rosette-like features can easily be identified from routine histological slides and the relative risk in patients with non-metastatic, conventional osteosarcoma is as high as other well known prognostic factors, including large size and poor chemotherapy effect.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalJournal of Clinical Pathology
Issue number11
Publication statusPublished - 2003 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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