Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

Kenichiro Yabuki; Daisuke Sano; Osamu Shiono; Yasuhiro Arai; Hideaki Takahashi; Yoshihiro Chiba; Teruhiko Tanabe; Goshi Nishimura; Masahiro Takahashi; Takahide Taguchi; Tomohiro Kaneta; Masaharu Hata; Nobuhiko Oridate

doi:10.1002/hed.24488

Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

Kenichiro Yabuki, Daisuke Sano, Osamu Shiono, Yasuhiro Arai, Hideaki Takahashi, Yoshihiro Chiba, Teruhiko Tanabe, Goshi Nishimura, Masahiro Takahashi, Takahide Taguchi, Tomohiro Kaneta, Masaharu Hata, Nobuhiko Oridate

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy. Methods: This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan–Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p <.001), nodal metastasis (p =.011), and applied chemotherapy regimen (p =.004) were found to be independent prognostic factors for DFS. Conclusion: The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy.

Original language	English
Pages (from-to)	1666-1671
Number of pages	6
Journal	Head and Neck
Volume	38
Issue number	11
DOIs	https://doi.org/10.1002/hed.24488
Publication status	Published - 2016 Nov 1
Externally published	Yes

Keywords

concurrent chemoradiotherapy
metabolic tumor volume
piriform sinus carcinoma
radiotherapy
survival

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.24488

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Yabuki, K., Sano, D., Shiono, O., Arai, Y., Takahashi, H., Chiba, Y., Tanabe, T., Nishimura, G., Takahashi, M., Taguchi, T., Kaneta, T., Hata, M., & Oridate, N. (2016). Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy. Head and Neck, 38(11), 1666-1671. https://doi.org/10.1002/hed.24488

Yabuki, K, Sano, D, Shiono, O, Arai, Y, Takahashi, H, Chiba, Y, Tanabe, T, Nishimura, G, Takahashi, M, Taguchi, T, Kaneta, T, Hata, M & Oridate, N 2016, 'Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy', Head and Neck, vol. 38, no. 11, pp. 1666-1671. https://doi.org/10.1002/hed.24488

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title = "Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy",

abstract = "Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy. Methods: This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan–Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p <.001), nodal metastasis (p =.011), and applied chemotherapy regimen (p =.004) were found to be independent prognostic factors for DFS. Conclusion: The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy.",

keywords = "concurrent chemoradiotherapy, metabolic tumor volume, piriform sinus carcinoma, radiotherapy, survival",

author = "Kenichiro Yabuki and Daisuke Sano and Osamu Shiono and Yasuhiro Arai and Hideaki Takahashi and Yoshihiro Chiba and Teruhiko Tanabe and Goshi Nishimura and Masahiro Takahashi and Takahide Taguchi and Tomohiro Kaneta and Masaharu Hata and Nobuhiko Oridate",

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year = "2016",

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doi = "10.1002/hed.24488",

language = "English",

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T1 - Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

AU - Yabuki, Kenichiro

AU - Sano, Daisuke

AU - Shiono, Osamu

AU - Arai, Yasuhiro

AU - Takahashi, Hideaki

AU - Chiba, Yoshihiro

AU - Tanabe, Teruhiko

AU - Nishimura, Goshi

AU - Takahashi, Masahiro

AU - Taguchi, Takahide

AU - Kaneta, Tomohiro

AU - Hata, Masaharu

AU - Oridate, Nobuhiko

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy. Methods: This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan–Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p <.001), nodal metastasis (p =.011), and applied chemotherapy regimen (p =.004) were found to be independent prognostic factors for DFS. Conclusion: The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy.

AB - Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy. Methods: This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan–Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p <.001), nodal metastasis (p =.011), and applied chemotherapy regimen (p =.004) were found to be independent prognostic factors for DFS. Conclusion: The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy.

KW - concurrent chemoradiotherapy

KW - metabolic tumor volume

KW - piriform sinus carcinoma

KW - radiotherapy

KW - survival

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Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

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