TY - JOUR
T1 - Prognostic value of home heart rate for cardiovascular mortality in the general population
T2 - The Ohasama study
AU - Hozawa, Atsushi
AU - Ohkubo, Takayoshi
AU - Kikuya, Masahiro
AU - Ugajin, Takashi
AU - Yamaguchi, Junko
AU - Asayama, Kei
AU - Metoki, Hirohito
AU - Ohmori, Kaori
AU - Hoshi, Haruhisa
AU - Hashimoto, Junichiro
AU - Satoh, Hiroshi
AU - Tsuji, Ichiro
AU - Imai, Yutaka
N1 - Funding Information:
This work was supported by Grants for Scientific Research (13470085, 13671095, 14657600, and 1437021) and for Japan Society for the Promotion of Science (JSPS)Research (1410301) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; research grants from Junkanki-byo Itaku Kenkyu (11C-5; 1999, 2000, 2001); research grant (2000, 2001) from the Japan Atherosclerosis Prevention Fund; a grant from the Japan Cardiovascular Research Foundation (2000, 2001 and 2002); and by a Health Science Research Grant on Health Services (H12-Iryo-002, 2000 and 2001; H13-21 Seiki [Seikatsu]-19, 2001; H13-Kenko-006, 2001) from the Ministry of Health, Labour, and Welfare of Japan.
PY - 2004/11
Y1 - 2004/11
N2 - Recently, the advantages of self-measurement of blood pressure (BP) at home have been recognized. The same advantages could also be applicable to resting heart rate (HR) values assessed at home using a device designed for home BP measurement. However, there have been no studies investigating whether home HR values predict the risk of cardiovascular disease mortality. We therefore investigated the usefulness of HR values in predicting cardiovascular mortality using a device that allowed self-measurement of BP and HR at home. The association between the home-measured resting HR and the 10-year risk of cardiovascular mortality was examined in 1780 Japanese individuals ≥40 years of age who had no significant arrhythmias. A Cox proportional hazards model that adjusted for major risk factors was used. An increase of 5 beats/min in the morning home HR measurement was associated with a 17% increase in the risk of cardiovascular mortality (95% confidence interval 5% to 30%). This relationship was also statistically significant after adjustment for home BP values. Even when home-measured systolic BP was within the normal range (<135 mm Hg), subjects with HR ≥70 beats/min had a higher risk of cardiovascular mortality (relative hazard 2.16, 95% confidence interval 1.21 to 3.85) than those with normal systolic BP and HR values. Self-measurement of HR at home, together with self-measurement of BP, is a simple method of providing useful clinical information for assessing cardiovascular risk.
AB - Recently, the advantages of self-measurement of blood pressure (BP) at home have been recognized. The same advantages could also be applicable to resting heart rate (HR) values assessed at home using a device designed for home BP measurement. However, there have been no studies investigating whether home HR values predict the risk of cardiovascular disease mortality. We therefore investigated the usefulness of HR values in predicting cardiovascular mortality using a device that allowed self-measurement of BP and HR at home. The association between the home-measured resting HR and the 10-year risk of cardiovascular mortality was examined in 1780 Japanese individuals ≥40 years of age who had no significant arrhythmias. A Cox proportional hazards model that adjusted for major risk factors was used. An increase of 5 beats/min in the morning home HR measurement was associated with a 17% increase in the risk of cardiovascular mortality (95% confidence interval 5% to 30%). This relationship was also statistically significant after adjustment for home BP values. Even when home-measured systolic BP was within the normal range (<135 mm Hg), subjects with HR ≥70 beats/min had a higher risk of cardiovascular mortality (relative hazard 2.16, 95% confidence interval 1.21 to 3.85) than those with normal systolic BP and HR values. Self-measurement of HR at home, together with self-measurement of BP, is a simple method of providing useful clinical information for assessing cardiovascular risk.
KW - Heart rate
KW - blood pressure
KW - cardiovascular disease
KW - mortality
KW - population
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U2 - 10.1016/j.amjhyper.2004.06.019
DO - 10.1016/j.amjhyper.2004.06.019
M3 - Article
C2 - 15533725
AN - SCOPUS:7944235941
SN - 0895-7061
VL - 17
SP - 1005
EP - 1010
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 11
ER -