Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy

Satoko Suzuki-Shibata, Yayoi Yamamoto, Tetsuo Yoshida, Nobutaka Mizoguchi, Tetsuo Nonaka, Akira Kubota, Hiroto Narimatsu, Yohei Miyagi, Toshiaki Kobayashi, Tomohiro Kaneta, Tomio Inoue

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Purpose: This study aimed to evaluate the predictive and prognostic value of FDG PET/CT-based volumetric parameters in patients with oral tongue squamous cell carcinoma (OTSCC) treated by superselective intra-arterial chemoradiotherapy (IA-CRT). Methods: We conducted a retrospective study including 33 patients with biopsy-proven OTSCC between May 2007 and February 2016. All of the patients were treated by IA-CRT. Pretreatment SUVmax and metabolic tumor volume (MTV) of the primary tumor were measured. The SUV thresholds of 2.5 and 5.0 were used. Progression-free survival (PFS) and overall survival (OS) were chosen as endpoints to evaluate prognosis. Univariate and multivariate analyses were performed to assess the potential independent effect of FDG PET/CT parameters. Results: The median follow-up for surviving patients was 40.7 months (range 6.0–107.5 months). In univariate and multivariate analyses, SUVmax and MTV (5.0) were independent prognostic factors for PFS. In univariate analysis, SUVmax failed to predict OS. MTV (5.0) was a significant prognostic factor for OS, but multivariate analysis failed to show statistical independence because it could not exclude the possibility of an artifact due to N stage. Conclusions: FDG PET/CT-based volumetric parameters may be significant prognostic markers for survival of patients with OTSCC who are treated by IA-CRT.

Original languageEnglish
Pages (from-to)740-747
Number of pages8
JournalJapanese Journal of Radiology
Volume35
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • FDG PET/CT
  • Metabolic tumor volume
  • Oral tongue squamous cell carcinoma

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