Programmable reactions and diffusion using DNA for pattern formation in hydrogel medium

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12 Citations (Scopus)


We demonstrate a method of pattern formation based on an artificial reaction diffusion system in hydrogel medium. By designing both the reaction term and the diffusion term of the system, we have succeeded in generating a sustainable DNA pattern in the gel. A DNA logic gate anchored in the gel detected the diffused molecules from distant source points to mark the equidistant region from the source points, which produced a Voronoi pattern in the gel. Combined with a diffusion modulation method for DNA molecules, the Voronoi pattern was modified as a weighted Voronoi pattern with different morphologies. The proposed framework will be useful in designing a structured gel system responsive to molecular signals.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalMolecular Systems Design and Engineering
Issue number3
Publication statusPublished - 2019 Jun

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Chemical Engineering (miscellaneous)
  • Biomedical Engineering
  • Energy Engineering and Power Technology
  • Process Chemistry and Technology
  • Industrial and Manufacturing Engineering
  • Materials Chemistry


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