Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

Akifumi Yoshikawa; Mitsutoshi Nakada; Takuya Watanabe; Yutaka Hayashi; Hemragul Sabit; Yukinari Kato; Shioto Suzuki; Akishi Ooi; Hiroshi Sato; Jun Ichiro Hamada

doi:10.1007/s10014-012-0118-9

Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

Akifumi Yoshikawa, Mitsutoshi Nakada, Takuya Watanabe, Yutaka Hayashi, Hemragul Sabit, Yukinari Kato, Shioto Suzuki, Akishi Ooi, Hiroshi Sato, Jun Ichiro Hamada

MED - Medical Sciences

Kanazawa University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.

Original language	English
Pages (from-to)	175-179
Number of pages	5
Journal	Brain Tumor Pathology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/s10014-012-0118-9
Publication status	Published - 2013 Jul

Keywords

Adult
IDH-1
MGMT
Medulla oblongata
Primary glioblastoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10014-012-0118-9

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title = "Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation",

abstract = "A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.",

keywords = "Adult, IDH-1, MGMT, Medulla oblongata, Primary glioblastoma",

author = "Akifumi Yoshikawa and Mitsutoshi Nakada and Takuya Watanabe and Yutaka Hayashi and Hemragul Sabit and Yukinari Kato and Shioto Suzuki and Akishi Ooi and Hiroshi Sato and Hamada, {Jun Ichiro}",

year = "2013",

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doi = "10.1007/s10014-012-0118-9",

language = "English",

volume = "30",

pages = "175--179",

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T1 - Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

AU - Yoshikawa, Akifumi

AU - Nakada, Mitsutoshi

AU - Watanabe, Takuya

AU - Hayashi, Yutaka

AU - Sabit, Hemragul

AU - Kato, Yukinari

AU - Suzuki, Shioto

AU - Ooi, Akishi

AU - Sato, Hiroshi

AU - Hamada, Jun Ichiro

PY - 2013/7

Y1 - 2013/7

N2 - A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.

AB - A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.

KW - Adult

KW - IDH-1

KW - MGMT

KW - Medulla oblongata

KW - Primary glioblastoma

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AN - SCOPUS:84880832424

SN - 1433-7398

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JO - Brain Tumor Pathology

JF - Brain Tumor Pathology

IS - 3

ER -

Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

Abstract

Keywords

UN SDGs

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