TY - JOUR
T1 - Pronounced enhancement of ·NO-dependent antimicrobial action by an ·NO- oxidizing agent, imidazolineoxyl N-oxide
AU - Yoshida, K.
AU - Akaike, T.
AU - Doi, T.
AU - Sato, K.
AU - Ijiri, S.
AU - Suga, M.
AU - Ando, M.
AU - Maeda, H.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The antimicrobial action of ·NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes ·NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sato, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochemistry 32:827- 832, 1993). No appreciable fungicidal activity was observed in neutral ·NO solutions. Imidazolineoxyl N-oxide induced or enhanced fungicidal action in neutral or acidic ·NO solutions, respectively. Our results provide convincing evidence that ·NO is not a microbicidal molecular species.
AB - The antimicrobial action of ·NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes ·NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sato, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochemistry 32:827- 832, 1993). No appreciable fungicidal activity was observed in neutral ·NO solutions. Imidazolineoxyl N-oxide induced or enhanced fungicidal action in neutral or acidic ·NO solutions, respectively. Our results provide convincing evidence that ·NO is not a microbicidal molecular species.
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M3 - Comment/debate
C2 - 8335388
AN - SCOPUS:0027336970
SN - 0019-9567
VL - 61
SP - 3552
EP - 3555
JO - Infection and Immunity
JF - Infection and Immunity
IS - 8
ER -
