Protective effect of Ginkgo extract on rat brain with transient middle cerebral artery occlusion

W. R. Zhang, T. Hayashi, H. Kitagawa, C. Sasaki, K. Sakai, H. Warita, J. M. Wang, Y. Shiro, M. Uchida, K. Abe

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


It has been empirically known that Ginkgo extract is useful for reducing many symptoms associated with cerebral blood flow (CBF) insufficiency, but its mechanisms have been uncertain. In the present study, therefore, we gave Ginkgo extract to rats with per os digestion, and investigated its effect on CBF and ischemic brain damage with middle cerebral artery occlusion (MCAO). The treatment with Ginkgo extract (10 mg 100 g-1 rat) increased CBF in the normal condition, but the degree of increase in CBF was lesser during and after MCAO. TTC staining showed that infarct volume was reduced with Ginkgo treatment. TUNEL and HSP72 immunostaining confirmed the protective effect of Ginkgo treatment reducing numbers of TUNEL and HSP72 positive cells. Immunohistochemical analysis showed that caspase-3 expression was less abundant in Ginkgo treated rats. The present results suggest that Ginkgo extract contains a substance which increases normal CBF and reduces ischemic brain damage.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalNeurological research
Issue number5
Publication statusPublished - 2000 Aug 15
Externally publishedYes


  • Caspase-3
  • Ginkgo extract
  • HSP72
  • Ischemia
  • MCAO

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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