Protective effect of soy isoflavone genistein on ischemia-reperfusion in the rat small intestine

Yuki Sato, Shirou Itagaki, Setsu Oikawa, Jiro Ogura, Masaki Kobayashi, Takeshi Hirano, Mitsuru Sugawara, Ken Iseki

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated.We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats.We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.

Original languageEnglish
Pages (from-to)1448-1454
Number of pages7
JournalBiological and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - 2011 Sept
Externally publishedYes


  • Antioxidant
  • Genistein
  • Intestine
  • Ischemia-reperfusion
  • Nutrition

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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