Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature

Tetsuya Akaishi; Ken Yasaka; Michiaki Abe; Hiroshi Fujii; Mika Watanabe; Tsuyoshi Shirai; Kota Ishizawa; Shin Takayama; Yutaka Kagaya; Hideo Harigae; Tadashi Ishii

doi:10.1002/jgf2.281

Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature

Tetsuya Akaishi, Ken Yasaka, Michiaki Abe, Hiroshi Fujii, Mika Watanabe, Tsuyoshi Shirai, Kota Ishizawa, Shin Takayama, Yutaka Kagaya, Hideo Harigae, Tadashi Ishii

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Abstract

A 30-year-old man with severe hypoalbuminemia (serum albumin: 0.9 g/dL) was admitted with severe bilateral leg edema and unilateral pleural effusion. Serum anti-SS-A and SS-B antibody levels were abnormally elevated, and his symptoms fulfilled the diagnostic criteria for Sjögren's syndrome. Technetium-99m albumin scintigraphy revealed protein leakage from a large area of the small intestine. Immunohistochemistry revealed perivascular deposition of C1q, C3d, and immunoglobulin G in the duodenal mucosa. The patient was diagnosed with protein-losing gastroenteropathy associated with Sjögren's syndrome. Within 2 months of treatment with oral prednisolone and mycophenolate mofetil, the clinical symptoms of hypoalbuminemia and Sjögren's syndrome disappeared completely.

Original language	English
Pages (from-to)	24-28
Number of pages	5
Journal	Journal of General and Family Medicine
Volume	21
Issue number	1
DOIs	https://doi.org/10.1002/jgf2.281
Publication status	Published - 2020 Jan

Keywords

Sjögren's syndrome
human serum albumin scintigraphy
hypoalbuminemia
protein-losing gastroenteropathy

ASJC Scopus subject areas

Family Practice
Geriatrics and Gerontology
Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jgf2.281

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Akaishi, T., Yasaka, K., Abe, M., Fujii, H., Watanabe, M., Shirai, T., Ishizawa, K., Takayama, S., Kagaya, Y., Harigae, H., & Ishii, T. (2020). Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature. Journal of General and Family Medicine, 21(1), 24-28. https://doi.org/10.1002/jgf2.281

Akaishi, T, Yasaka, K, Abe, M , Fujii, H, Watanabe, M, Shirai, T, Ishizawa, K, Takayama, S, Kagaya, Y, Harigae, H & Ishii, T 2020, 'Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature', Journal of General and Family Medicine, vol. 21, no. 1, pp. 24-28. https://doi.org/10.1002/jgf2.281

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abstract = "A 30-year-old man with severe hypoalbuminemia (serum albumin: 0.9 g/dL) was admitted with severe bilateral leg edema and unilateral pleural effusion. Serum anti-SS-A and SS-B antibody levels were abnormally elevated, and his symptoms fulfilled the diagnostic criteria for Sj{\"o}gren's syndrome. Technetium-99m albumin scintigraphy revealed protein leakage from a large area of the small intestine. Immunohistochemistry revealed perivascular deposition of C1q, C3d, and immunoglobulin G in the duodenal mucosa. The patient was diagnosed with protein-losing gastroenteropathy associated with Sj{\"o}gren's syndrome. Within 2 months of treatment with oral prednisolone and mycophenolate mofetil, the clinical symptoms of hypoalbuminemia and Sj{\"o}gren's syndrome disappeared completely.",

keywords = "Sj{\"o}gren's syndrome, human serum albumin scintigraphy, hypoalbuminemia, protein-losing gastroenteropathy",

author = "Tetsuya Akaishi and Ken Yasaka and Michiaki Abe and Hiroshi Fujii and Mika Watanabe and Tsuyoshi Shirai and Kota Ishizawa and Shin Takayama and Yutaka Kagaya and Hideo Harigae and Tadashi Ishii",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association",

year = "2020",

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doi = "10.1002/jgf2.281",

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AU - Akaishi, Tetsuya

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AU - Abe, Michiaki

AU - Fujii, Hiroshi

AU - Watanabe, Mika

AU - Shirai, Tsuyoshi

AU - Ishizawa, Kota

AU - Takayama, Shin

AU - Kagaya, Yutaka

AU - Harigae, Hideo

AU - Ishii, Tadashi

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AB - A 30-year-old man with severe hypoalbuminemia (serum albumin: 0.9 g/dL) was admitted with severe bilateral leg edema and unilateral pleural effusion. Serum anti-SS-A and SS-B antibody levels were abnormally elevated, and his symptoms fulfilled the diagnostic criteria for Sjögren's syndrome. Technetium-99m albumin scintigraphy revealed protein leakage from a large area of the small intestine. Immunohistochemistry revealed perivascular deposition of C1q, C3d, and immunoglobulin G in the duodenal mucosa. The patient was diagnosed with protein-losing gastroenteropathy associated with Sjögren's syndrome. Within 2 months of treatment with oral prednisolone and mycophenolate mofetil, the clinical symptoms of hypoalbuminemia and Sjögren's syndrome disappeared completely.

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Protein-losing gastroenteropathy with severe hypoalbuminemia associated with Sjögren’s syndrome: A case report and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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