TY - JOUR
T1 - Pseudolymphomatous angiokeratoma
T2 - Report of three cases and an immunohistological study
AU - Okuyama, R.
AU - Masu, T.
AU - Mizuashi, M.
AU - Watanabe, M.
AU - Tagami, H.
AU - Aiba, S.
PY - 2009/3
Y1 - 2009/3
N2 - Background. Pseudolymphomatous angiokeratoma (PA), originally termed 'acral pseudolymphomatous angiokeratoma of children', is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate. Methods. We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick-walled vessels. Results. Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20. Conclusion. Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T-cell to B-cell predominance.
AB - Background. Pseudolymphomatous angiokeratoma (PA), originally termed 'acral pseudolymphomatous angiokeratoma of children', is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate. Methods. We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick-walled vessels. Results. Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20. Conclusion. Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T-cell to B-cell predominance.
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U2 - 10.1111/j.1365-2230.2008.02849.x
DO - 10.1111/j.1365-2230.2008.02849.x
M3 - Article
C2 - 18681875
AN - SCOPUS:58549088986
SN - 0307-6938
VL - 34
SP - 161
EP - 165
JO - Clinical and Experimental Dermatology
JF - Clinical and Experimental Dermatology
IS - 2
ER -