Pseurotin A and its analogues as inhibitors of immunoglobuline E production

Minoru Ishikawa; Tomohisa Ninomiya; Hirotomo Akabane; Nobuaki Kushida; Go Tsujiuchi; Makoto Ohyama; Shuichi Gomi; Keiko Shito; Takashi Murata

doi:10.1016/j.bmcl.2009.01.029

Pseurotin A and its analogues as inhibitors of immunoglobuline E production

Minoru Ishikawa, Tomohisa Ninomiya, Hirotomo Akabane, Nobuaki Kushida, Go Tsujiuchi, Makoto Ohyama, Shuichi Gomi, Keiko Shito, Takashi Murata

LIF - Molecular and Chemical Life Science

Meiji Holdings Co., Ltd.

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC₅₀ of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.

Original language	English
Pages (from-to)	1457-1460
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2009.01.029
Publication status	Published - 2009 Mar 1

Keywords

10-Deoxypseurotin A
Immunosuppressive activity
Inhibitor of IgE production
Pseurotin A
Structure-activity relationship
Synerazol

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10.1016/j.bmcl.2009.01.029

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abstract = "A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.",

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AU - Ishikawa, Minoru

AU - Ninomiya, Tomohisa

AU - Akabane, Hirotomo

AU - Kushida, Nobuaki

AU - Tsujiuchi, Go

AU - Ohyama, Makoto

AU - Gomi, Shuichi

AU - Shito, Keiko

AU - Murata, Takashi

PY - 2009/3/1

Y1 - 2009/3/1

N2 - A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.

AB - A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.

KW - 10-Deoxypseurotin A

KW - Immunosuppressive activity

KW - Inhibitor of IgE production

KW - Pseurotin A

KW - Structure-activity relationship

KW - Synerazol

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JO - Bioorganic and Medicinal Chemistry Letters

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Pseurotin A and its analogues as inhibitors of immunoglobuline E production

Abstract

Keywords

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