A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.
- 10-Deoxypseurotin A
- Immunosuppressive activity
- Inhibitor of IgE production
- Pseurotin A
- Structure-activity relationship