Tomotaka Shoji, Yuka Endo, Shin Fukudo

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)


Epidemiological studies have indicated that there is a convincing association between psychological disorders, particularly anxiety and depression, and functional dyspepsia. Bidirectional gut-brain signals are processed by homeostaticinteroceptive brain regions in humans, and these areas show abnormalities in patients with functional dyspepsia. The evidence warrants use of a biopsychosocial model for the research and treatment of patients with functional dyspepsia. Some types of antidepressants are effective for improving symptoms and quality of life. However, these agents should be cautiously used in patients with comorbid psychological conditions due to their high rates of adverse effects. Psychological interventions in patients with functional dyspepsia remain under-researched, but cognitive behavioral therapy may ameliorate distress due to symptoms and improve health-­ related quality of life in some refractory patients. Understanding of the neurogastroenterological mechanism will help to elucidate the association between psychological disorders and functional dyspepsia.

Original languageEnglish
Title of host publicationFunctional Dyspepsia
Subtitle of host publicationEvidences in Pathophysiology and Treatment
PublisherSpringer Singapore
Number of pages11
ISBN (Electronic)9789811310744
ISBN (Print)9789811310737
Publication statusPublished - 2018 Jan 1


  • Anxiety
  • Brain imaging
  • Functional dyspepsia
  • Gut-brain axis
  • Psychotherapy


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