Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels

Davod Alizadehrad, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50μm, hematocrits from 20% to 45%, and shear rates from 20 to 150s-1 using a particle-based model with parallel computing. The apparent viscosity predicted by the simulation was in good agreement with previous experimental results. We quantified the deformation of red blood cells as a function of radial position. The numerical results demonstrated that because of the shape transition in response to local shear stress and the wall effect, the radial variation of red blood cell deformation in relatively large microvessels could be classified into three different regions: near-center, middle, and near-wall regions. Effects of the local shear stress and wall varied with vessel diameter, hematocrit, and shear rate.

Original languageEnglish
Pages (from-to)2684-2689
Number of pages6
JournalJournal of Biomechanics
Issue number15
Publication statusPublished - 2012 Oct 11


  • Dense suspension
  • Microcirculation
  • Numerical simulation
  • Red blood cell deformation


Dive into the research topics of 'Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels'. Together they form a unique fingerprint.

Cite this