Quantitative analysis of bile acid 3-sulfates by LC-ESI-oa-TOF mass spectrometer

Yutaka Takahashi; Tetsuichiro Morita; Jun Tamura; Kiyotaka Konuma; Yoshihisa Ueda; Fumio Kunihiro; Nariyasu Mano; Junichi Goto

Quantitative analysis of bile acid 3-sulfates by LC-ESI-oa-TOF mass spectrometer

Yutaka Takahashi, Tetsuichiro Morita, Jun Tamura, Kiyotaka Konuma, Yoshihisa Ueda, Fumio Kunihiro, Nariyasu Mano, Junichi Goto

HOSP - University Hospital (not affiliated with any section)

Research output: Contribution to conference › Paper › peer-review

Abstract

The quantitative analysis of bile acid 3-sulfates by using liquid chromatography - time of flight mass spectrometry (LC-TOFMS) is described. Recently, the TOFMS is used as a combination with a LC. However, most of LC-TOFMS has a Time-to-Digital Converter (TDC) as a data acquisition system. In case of using a TDC, it has limited dynamic range for sample concentration. Most recently, we developed a new type of LC-TOFMS "AccuTQF™", which has an Analog-to-Digital Converter (ADC) as a data acquisition system. By using an ADC, it is possible to accomplish a quantitative analysis with a wide dynamic range. The high-selectivity quantitative determination is expected, because highest sensitivity is obtained with high mass resolution (>6,000) with a TOF instrument.

Original language	English
Pages	511-512
Number of pages	2
Publication status	Published - 2002
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2002 Jun 2 → 2002 Jun 6

Conference

Conference	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	02/6/2 → 02/6/6

Cite this

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abstract = "The quantitative analysis of bile acid 3-sulfates by using liquid chromatography - time of flight mass spectrometry (LC-TOFMS) is described. Recently, the TOFMS is used as a combination with a LC. However, most of LC-TOFMS has a Time-to-Digital Converter (TDC) as a data acquisition system. In case of using a TDC, it has limited dynamic range for sample concentration. Most recently, we developed a new type of LC-TOFMS {"}AccuTQF{\texttrademark}{"}, which has an Analog-to-Digital Converter (ADC) as a data acquisition system. By using an ADC, it is possible to accomplish a quantitative analysis with a wide dynamic range. The high-selectivity quantitative determination is expected, because highest sensitivity is obtained with high mass resolution (>6,000) with a TOF instrument.",

author = "Yutaka Takahashi and Tetsuichiro Morita and Jun Tamura and Kiyotaka Konuma and Yoshihisa Ueda and Fumio Kunihiro and Nariyasu Mano and Junichi Goto",

year = "2002",

language = "English",

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note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

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T1 - Quantitative analysis of bile acid 3-sulfates by LC-ESI-oa-TOF mass spectrometer

AU - Takahashi, Yutaka

AU - Morita, Tetsuichiro

AU - Tamura, Jun

AU - Konuma, Kiyotaka

AU - Ueda, Yoshihisa

AU - Kunihiro, Fumio

AU - Mano, Nariyasu

AU - Goto, Junichi

PY - 2002

Y1 - 2002

N2 - The quantitative analysis of bile acid 3-sulfates by using liquid chromatography - time of flight mass spectrometry (LC-TOFMS) is described. Recently, the TOFMS is used as a combination with a LC. However, most of LC-TOFMS has a Time-to-Digital Converter (TDC) as a data acquisition system. In case of using a TDC, it has limited dynamic range for sample concentration. Most recently, we developed a new type of LC-TOFMS "AccuTQF™", which has an Analog-to-Digital Converter (ADC) as a data acquisition system. By using an ADC, it is possible to accomplish a quantitative analysis with a wide dynamic range. The high-selectivity quantitative determination is expected, because highest sensitivity is obtained with high mass resolution (>6,000) with a TOF instrument.

AB - The quantitative analysis of bile acid 3-sulfates by using liquid chromatography - time of flight mass spectrometry (LC-TOFMS) is described. Recently, the TOFMS is used as a combination with a LC. However, most of LC-TOFMS has a Time-to-Digital Converter (TDC) as a data acquisition system. In case of using a TDC, it has limited dynamic range for sample concentration. Most recently, we developed a new type of LC-TOFMS "AccuTQF™", which has an Analog-to-Digital Converter (ADC) as a data acquisition system. By using an ADC, it is possible to accomplish a quantitative analysis with a wide dynamic range. The high-selectivity quantitative determination is expected, because highest sensitivity is obtained with high mass resolution (>6,000) with a TOF instrument.

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T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

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Quantitative analysis of bile acid 3-sulfates by LC-ESI-oa-TOF mass spectrometer

Abstract

Conference

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