The quantitative analysis of bile acid 3-sulfates by using liquid chromatography - time of flight mass spectrometry (LC-TOFMS) is described. Recently, the TOFMS is used as a combination with a LC. However, most of LC-TOFMS has a Time-to-Digital Converter (TDC) as a data acquisition system. In case of using a TDC, it has limited dynamic range for sample concentration. Most recently, we developed a new type of LC-TOFMS "AccuTQF™", which has an Analog-to-Digital Converter (ADC) as a data acquisition system. By using an ADC, it is possible to accomplish a quantitative analysis with a wide dynamic range. The high-selectivity quantitative determination is expected, because highest sensitivity is obtained with high mass resolution (>6,000) with a TOF instrument.
|Number of pages||2|
|Publication status||Published - 2002|
|Event||Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States|
Duration: 2002 Jun 2 → 2002 Jun 6
|Conference||Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics|
|Period||02/6/2 → 02/6/6|