TY - JOUR
T1 - Quantitative evaluation of reactive oxygen and chlorine species generated by discharge in PBS
AU - Honda, Ryosuke
AU - Sasaki, Shota
AU - Takashima, Keisuke
AU - Sato, Takehiko
AU - Kaneko, Toshiro
N1 - Publisher Copyright:
© 2019 The Japan Society of Applied Physics.
PY - 2019
Y1 - 2019
N2 - While plasma devices delivering combined stimuli such as electric current and reactive species to biological tissues are promising medical tools, improvements in invasiveness and controllability are required for practical use. We herein demonstrated stable discharge generation in phosphate-buffered saline using thin (φ2.2 mm) and bendable cable without working gas supply toward the combination use with endoscope proposed as less invasive surgery. The discharge generated H2O2, OH, and ClO-/HClO in accordance with the discharge duration, whereas only electric current treatment without the discharge generated relatively low level of ClO-/HClO. In particular, the increase rate of the ClO-/HClO generation to the discharge duration was lower than that of H2O2 generation, showing the potential of the generation ratio control of ClO-/HClO as RCS (reactive chlorine species) to H2O2 as ROS (reactive oxygen species).
AB - While plasma devices delivering combined stimuli such as electric current and reactive species to biological tissues are promising medical tools, improvements in invasiveness and controllability are required for practical use. We herein demonstrated stable discharge generation in phosphate-buffered saline using thin (φ2.2 mm) and bendable cable without working gas supply toward the combination use with endoscope proposed as less invasive surgery. The discharge generated H2O2, OH, and ClO-/HClO in accordance with the discharge duration, whereas only electric current treatment without the discharge generated relatively low level of ClO-/HClO. In particular, the increase rate of the ClO-/HClO generation to the discharge duration was lower than that of H2O2 generation, showing the potential of the generation ratio control of ClO-/HClO as RCS (reactive chlorine species) to H2O2 as ROS (reactive oxygen species).
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U2 - 10.7567/1347-4065/ab4571
DO - 10.7567/1347-4065/ab4571
M3 - Article
AN - SCOPUS:85073219348
SN - 0021-4922
VL - 58
JO - Japanese Journal of Applied Physics
JF - Japanese Journal of Applied Physics
IS - 10
M1 - 106002
ER -