TY - JOUR
T1 - Radiation therapy for limited-stage small-cell esophageal cancer
AU - Nemoto, Kenji
AU - Zhao, Heng Jiang
AU - Goto, Takumi
AU - Ogawa, Yoshihiro
AU - Takai, Yoshihiro
AU - Matsushita, Haruo
AU - Takeda, Ken
AU - Takahashi, Chiaki
AU - Saito, Haruo
AU - Yamada, Shogo
PY - 2002
Y1 - 2002
N2 - Between 1985 and 1999, 20 patients with limited-stage smallcell carcinoma of the esophagus (SCEC) received radiation therapy at Tohoku University Hospital and Miyagi Cancer Center Hospital. Twelve patients received definitive radiation therapy and eight patients received postoperative prophylactic irradiation after surgery. The 1-, 2-, and 5-year survival rates of all cases were 44%, 37%, and 19%, respectively. Distant metastasis was the most frequent pattern of recurrence. Survival rates differed significantly between the 6 patients who were not treated with chemotherapy (median survival time, 5 months) and the 14 patients who were (24 months) (p = 0.0061). Good local control rates can be obtained by definite or postoperative radiation therapy for SCEC. However, SCEC should be regarded as a systemic disease, and chemotherapy should be given. Multiinstitutional studies are needed to obtain sufficiently large populations for investigation and optimization of local therapy for this disease.
AB - Between 1985 and 1999, 20 patients with limited-stage smallcell carcinoma of the esophagus (SCEC) received radiation therapy at Tohoku University Hospital and Miyagi Cancer Center Hospital. Twelve patients received definitive radiation therapy and eight patients received postoperative prophylactic irradiation after surgery. The 1-, 2-, and 5-year survival rates of all cases were 44%, 37%, and 19%, respectively. Distant metastasis was the most frequent pattern of recurrence. Survival rates differed significantly between the 6 patients who were not treated with chemotherapy (median survival time, 5 months) and the 14 patients who were (24 months) (p = 0.0061). Good local control rates can be obtained by definite or postoperative radiation therapy for SCEC. However, SCEC should be regarded as a systemic disease, and chemotherapy should be given. Multiinstitutional studies are needed to obtain sufficiently large populations for investigation and optimization of local therapy for this disease.
KW - Chemotherapy
KW - Esophageal cancer
KW - Radiotherapy
KW - Small-cell carcinoma
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=0036340604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036340604&partnerID=8YFLogxK
U2 - 10.1097/00000421-200208000-00017
DO - 10.1097/00000421-200208000-00017
M3 - Article
C2 - 12151974
AN - SCOPUS:0036340604
SN - 0277-3732
VL - 25
SP - 404
EP - 407
JO - American Journal of Clinical Oncology
JF - American Journal of Clinical Oncology
IS - 4
ER -
