Rapid library synthesis of amphiphiles based on a dioxinone scaffold and identification of nonlamellar liquid crystals

Shinichiro Fuse, Kentarou Nakamura, Yuto Mifune, Hironori Marubayashi, Ichiro Hijikuro, Shuichi Nojima, Hiroshi Tanaka, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Linear and branched amphiphiles with different lengths of lipids and different numbers of hydroxyl groups were rapidly synthesized based on a dioxinone scaffold. The liquid crystalline (LC) properties of the synthesized amphiphiles in excess water were investigated by polarizing optical microscopy and small-angle X-ray scattering (SAXS) analysis. Novel β-keto ester based amphiphiles that formed non-lamellar, inverted LC phases were identified.

Original languageEnglish
Pages (from-to)2806-2813
Number of pages8
JournalSynlett
Volume25
Issue number19
DOIs
Publication statusPublished - 2014 Oct 20

Keywords

  • alkylation
  • combinatorial chemistry
  • multicomponent reaction
  • nucleophilic addition
  • palladium

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