Rapid separation of shikimic acid from Chinese star anise (Illicium verum Hook. f.) with hot water extraction

Hiroki Ohira, Naota Torii, Taku M. Aida, Masaru Watanabe, Richard L. Smith

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Shikimic acid can be rapidly separated (ca. 5 min) from Chinese star anise with hot water extraction at temperatures of 120 °C or higher to obtain recoveries of 100%. Extraction recoveries of shikimic acid close to 97% can be obtained with water at 70 °C using slightly longer extraction times (ca. 10 min) than those at 120 °C. A semi-batch flow apparatus was used to study the effect of temperature, average particle size, water flow rate, and extraction time on the experimental recoveries. For 0.5 g Chinese star anise raw material that contained ca. 8% shikimic acid, 100% recoveries of shikimic acid could be obtained with 60 g water at 150 °C at 15 MPa in 4 min for star anise material having a particle size range from 355 to 600 μm. A one-site kinetic model was found to provide good correlation of the data and the kinetic parameters of the model could be written in terms of linearized contributions in temperature, average particle diameter and flow rate.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalSeparation and Purification Technology
Issue number1
Publication statusPublished - 2009 Sept 15


  • Orthomyxoviridae
  • Oseltamivir phosphate
  • Pandemic preparedness
  • Shikimic acid
  • Subcritical water
  • Tamiflu


Dive into the research topics of 'Rapid separation of shikimic acid from Chinese star anise (Illicium verum Hook. f.) with hot water extraction'. Together they form a unique fingerprint.

Cite this