Real-Time Cardiac Output Estimation of the Circulatory System Under Left Ventricular Assistance

Makoto Yoshizawa; Hiroshi Takeda; Makoto Miura; Tomoyuki Yambe; Yoshiaki Katahira; Shin Ichi Nitta

doi:10.1109/10.216410

Real-Time Cardiac Output Estimation of the Circulatory System Under Left Ventricular Assistance

Makoto Yoshizawa, Hiroshi Takeda, Makoto Miura, Tomoyuki Yambe, Yoshiaki Katahira, Shin Ichi Nitta

IDAC - PreClinical Research Center

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11 Citations (Scopus)

Abstract

A new method for indirect and real-time estimation of the cardiac output of the circulatory system supported by the left ventricular assist device (LVAD) was proposed. This method has low invasiveness and is useful for clinical application of the LVAD since it needs only two measurements: the outflow rate of blood from the LVAD and the aortic pressure. The proposed method is based on a system identification technique for the time series model of the cardiovascular system and requires less computational time than other methods with similar estimation accuracy. Hence, the proposed method could be implemented in a personal computer system and realize the on-line and real-time estimation of the instantaneous outflow rate of the natural heart. The efficiency and limitation of the method were discussed on the basis of the results obtained from in vitro experiment using a mock circulatory system and in vivo experiment using an adult goat. It was revealed that the method could obtain a fairly high correlation coefficient between the true stroke volume of the natural heart and its estimate of more than 0.99 (in vitro) or 0.95 (in vivo). This means that there is a fair possibility of applying the proposed estimation system to the clinical use.

Original language	English
Pages (from-to)	266-275
Number of pages	10
Journal	IEEE Transactions on Biomedical Engineering
Volume	40
Issue number	3
DOIs	https://doi.org/10.1109/10.216410
Publication status	Published - 1993 Mar

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@article{842518a995444f4192be5f4a95ad3941,

title = "Real-Time Cardiac Output Estimation of the Circulatory System Under Left Ventricular Assistance",

abstract = "A new method for indirect and real-time estimation of the cardiac output of the circulatory system supported by the left ventricular assist device (LVAD) was proposed. This method has low invasiveness and is useful for clinical application of the LVAD since it needs only two measurements: the outflow rate of blood from the LVAD and the aortic pressure. The proposed method is based on a system identification technique for the time series model of the cardiovascular system and requires less computational time than other methods with similar estimation accuracy. Hence, the proposed method could be implemented in a personal computer system and realize the on-line and real-time estimation of the instantaneous outflow rate of the natural heart. The efficiency and limitation of the method were discussed on the basis of the results obtained from in vitro experiment using a mock circulatory system and in vivo experiment using an adult goat. It was revealed that the method could obtain a fairly high correlation coefficient between the true stroke volume of the natural heart and its estimate of more than 0.99 (in vitro) or 0.95 (in vivo). This means that there is a fair possibility of applying the proposed estimation system to the clinical use.",

author = "Makoto Yoshizawa and Hiroshi Takeda and Makoto Miura and Tomoyuki Yambe and Yoshiaki Katahira and Nitta, {Shin Ichi}",

note = "Funding Information: Manuscript received Octob?r 2. 1992; revis?d Novemb?r 3, 1992. This work was support?d by Grant-in-Aid (No. 01890003 and 63750390) from the Japan Ministry of Education, Science and Culture. M. Yoshizawa is with the D?partment of KnOWledge-Bas?d Information Engin??ring, Toyohashi Univ?rsity of T?chnology, Toyohashi 441, Japan. H. Takeda is with the Department of Electrical Engineering, Faculty of Engineering, Tohoku University, Sendai 980, Japan. M. Miura is with th? Departm?nt of Thoracic Surgery, School of Medicine, Tohoku University, S?ndai 980, Japan. T. Yambe, Y. Katahira, and S. Nitta are with Research Institute for Chest Dis?as?s and Cancer, Tohoku University, Sendai 980, Japan. IEEE Log Numb?r 9206330.",

year = "1993",

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AU - Yoshizawa, Makoto

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AU - Miura, Makoto

AU - Yambe, Tomoyuki

AU - Katahira, Yoshiaki

AU - Nitta, Shin Ichi

N1 - Funding Information: Manuscript received Octob?r 2. 1992; revis?d Novemb?r 3, 1992. This work was support?d by Grant-in-Aid (No. 01890003 and 63750390) from the Japan Ministry of Education, Science and Culture. M. Yoshizawa is with the D?partment of KnOWledge-Bas?d Information Engin??ring, Toyohashi Univ?rsity of T?chnology, Toyohashi 441, Japan. H. Takeda is with the Department of Electrical Engineering, Faculty of Engineering, Tohoku University, Sendai 980, Japan. M. Miura is with th? Departm?nt of Thoracic Surgery, School of Medicine, Tohoku University, S?ndai 980, Japan. T. Yambe, Y. Katahira, and S. Nitta are with Research Institute for Chest Dis?as?s and Cancer, Tohoku University, Sendai 980, Japan. IEEE Log Numb?r 9206330.

PY - 1993/3

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N2 - A new method for indirect and real-time estimation of the cardiac output of the circulatory system supported by the left ventricular assist device (LVAD) was proposed. This method has low invasiveness and is useful for clinical application of the LVAD since it needs only two measurements: the outflow rate of blood from the LVAD and the aortic pressure. The proposed method is based on a system identification technique for the time series model of the cardiovascular system and requires less computational time than other methods with similar estimation accuracy. Hence, the proposed method could be implemented in a personal computer system and realize the on-line and real-time estimation of the instantaneous outflow rate of the natural heart. The efficiency and limitation of the method were discussed on the basis of the results obtained from in vitro experiment using a mock circulatory system and in vivo experiment using an adult goat. It was revealed that the method could obtain a fairly high correlation coefficient between the true stroke volume of the natural heart and its estimate of more than 0.99 (in vitro) or 0.95 (in vivo). This means that there is a fair possibility of applying the proposed estimation system to the clinical use.

AB - A new method for indirect and real-time estimation of the cardiac output of the circulatory system supported by the left ventricular assist device (LVAD) was proposed. This method has low invasiveness and is useful for clinical application of the LVAD since it needs only two measurements: the outflow rate of blood from the LVAD and the aortic pressure. The proposed method is based on a system identification technique for the time series model of the cardiovascular system and requires less computational time than other methods with similar estimation accuracy. Hence, the proposed method could be implemented in a personal computer system and realize the on-line and real-time estimation of the instantaneous outflow rate of the natural heart. The efficiency and limitation of the method were discussed on the basis of the results obtained from in vitro experiment using a mock circulatory system and in vivo experiment using an adult goat. It was revealed that the method could obtain a fairly high correlation coefficient between the true stroke volume of the natural heart and its estimate of more than 0.99 (in vitro) or 0.95 (in vivo). This means that there is a fair possibility of applying the proposed estimation system to the clinical use.

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JF - IEEE Transactions on Biomedical Engineering

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ER -

Real-Time Cardiac Output Estimation of the Circulatory System Under Left Ventricular Assistance

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