Real-time observation of angiogenesis under electrical stimulation

Yusuke Inoue; Tsuyoshi Sekitani; Itsuro Saito; Takashi Isoyama; Yusuke Abe; Takao Someya; Masaki Sekino

doi:10.11239/jsmbe.52.O-249

Real-time observation of angiogenesis under electrical stimulation

Yusuke Inoue, Tsuyoshi Sekitani, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Takao Someya, Masaki Sekino

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study is to investigate the effect of electrical stimulation on angiogenesis. We developed an implantable camera device which observes blood vessels in animal bodies with stimulating electrodes. This device was implanted under the goat skin for 60 days. Electrical stimulations were applied with a sinusoidal wave of 60 kHz and a current density of 300 uA/mm2. Angiogenesis was clearly observed in the non-stimulated chamber, while angiogenesis did not occur in the stimulated chamber. These results show that electrical stimulation of this condition has effective to suppress angiogenesis.

Original language	English
Pages (from-to)	O-249-O-250
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.O-249
Publication status	Published - 2014 Aug 17
Externally published	Yes

Keywords

Angiogenesis
Animal experiment
Bioelectronics
Biology
Microscope
Tissue engineering

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.11239/jsmbe.52.O-249

Cite this

@article{e0c548b32ad1484ab3d3d47f7289011b,

title = "Real-time observation of angiogenesis under electrical stimulation",

abstract = "The purpose of this study is to investigate the effect of electrical stimulation on angiogenesis. We developed an implantable camera device which observes blood vessels in animal bodies with stimulating electrodes. This device was implanted under the goat skin for 60 days. Electrical stimulations were applied with a sinusoidal wave of 60 kHz and a current density of 300 uA/mm2. Angiogenesis was clearly observed in the non-stimulated chamber, while angiogenesis did not occur in the stimulated chamber. These results show that electrical stimulation of this condition has effective to suppress angiogenesis.",

keywords = "Angiogenesis, Animal experiment, Bioelectronics, Biology, Microscope, Tissue engineering",

author = "Yusuke Inoue and Tsuyoshi Sekitani and Itsuro Saito and Takashi Isoyama and Yusuke Abe and Takao Someya and Masaki Sekino",

year = "2014",

month = aug,

day = "17",

doi = "10.11239/jsmbe.52.O-249",

language = "English",

volume = "52",

pages = "O--249--O--250",

journal = "BME = Bio medical engineering / henshu, Nihon ME Gakkai",

issn = "1347-443X",

publisher = "Nihon M E Gakkai",

}

TY - JOUR

T1 - Real-time observation of angiogenesis under electrical stimulation

AU - Inoue, Yusuke

AU - Sekitani, Tsuyoshi

AU - Saito, Itsuro

AU - Isoyama, Takashi

AU - Abe, Yusuke

AU - Someya, Takao

AU - Sekino, Masaki

PY - 2014/8/17

Y1 - 2014/8/17

N2 - The purpose of this study is to investigate the effect of electrical stimulation on angiogenesis. We developed an implantable camera device which observes blood vessels in animal bodies with stimulating electrodes. This device was implanted under the goat skin for 60 days. Electrical stimulations were applied with a sinusoidal wave of 60 kHz and a current density of 300 uA/mm2. Angiogenesis was clearly observed in the non-stimulated chamber, while angiogenesis did not occur in the stimulated chamber. These results show that electrical stimulation of this condition has effective to suppress angiogenesis.

AB - The purpose of this study is to investigate the effect of electrical stimulation on angiogenesis. We developed an implantable camera device which observes blood vessels in animal bodies with stimulating electrodes. This device was implanted under the goat skin for 60 days. Electrical stimulations were applied with a sinusoidal wave of 60 kHz and a current density of 300 uA/mm2. Angiogenesis was clearly observed in the non-stimulated chamber, while angiogenesis did not occur in the stimulated chamber. These results show that electrical stimulation of this condition has effective to suppress angiogenesis.

KW - Angiogenesis

KW - Animal experiment

KW - Bioelectronics

KW - Biology

KW - Microscope

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=84939451634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939451634&partnerID=8YFLogxK

U2 - 10.11239/jsmbe.52.O-249

DO - 10.11239/jsmbe.52.O-249

M3 - Article

AN - SCOPUS:84939451634

SN - 1347-443X

VL - 52

SP - O-249-O-250

JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai

JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai

ER -

Real-time observation of angiogenesis under electrical stimulation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this